CIS-2-AMINO-1-CYCLOPENTANECARBOXYLIC ACID

Base Information

• Chemical Name: CIS-2-AMINO-1-CYCLOPENTANECARBOXYLIC ACID
• CAS No.: 37910-65-9
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.159
• Hs Code.: 29224985
• Mol file: 37910-65-9.mol

Synonyms:Cyclopentanecarboxylicacid, 2-amino-, cis-;(1S,2R)-2-Aminocyclopentanecarboxylic acid;cis-2-Aminocyclopentane-1-carboxylic acid;cis-2-Aminocyclopentanecarboxylic acid;Cyclopentanecarboxylic acid, 2-amino-, (1S,2R)-;

Chemical Property of CIS-2-AMINO-1-CYCLOPENTANECARBOXYLIC ACID

Chemical Property:

• Appearance/Colour: White to off-white crystalline powder
• Melting Point: 218-220 °C
• Refractive Index: 1.4300 (estimate)
• Boiling Point: 264.72 °C at 760 mmHg
• Flash Point: 113.899 °C
• PSA: 63.32000
• Density: 1.19 g/cm³
• LogP: 0.89870
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

cis-2-Amino-1-cyclopentanecarboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CIS-2-AMINO-1-CYCLOPENTANECARBOXYLIC ACID

There total 123 articles about CIS-2-AMINO-1-CYCLOPENTANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1R,2S)-cis-2-benzyloxycarbonylamino-cyclopentane-1-carboxylic acid benzyl ester → (-)-cispentacin (122672-46-2,37910-65-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; under 760.051 Torr;

Reference yield: 95.0%

(1R,5S)-6-azabicyclo[3.2.0]heptan-7-one (39155-94-7) → (-)-cispentacin (122672-46-2,37910-65-9)

Guidance literature:

With hydrogenchloride; In water;

DOI:10.1039/P19910002276

Reference yield: 91.0%

(1R,2S)-2-phthalimidocyclopentane-1-carboxylic acid (186249-64-9) → (-)-cispentacin (122672-46-2,37910-65-9)

Guidance literature:

With methylamine; In ethanol; for 1.5h; Ambient temperature;

DOI:10.1016/S0957-4166(96)00465-X

upstream raw materials:

(1R,5S)-6-azabicyclo[3.2.0]heptan-7-one

(±)-cis-2-((tert-butoxycarbonyl)amino)cyclopentanecarboxylic acid

(-)-N-(tert-butyloxycarbonyl)-cis-2-aminocyclopentanecarboxylic acid

(1R,2S)-2-aminocyclopentanecarboxylic acid tert-butyl ester

Refernces

• 1、 Forró, Enik?,Galla, Zsolt,Fül?p, Ferenc. "The N-Hydroxymethyl Group as a Traceless Activating Group for the CAL-B-Catalysed Ring Cleavage of β-Lactams: A Type of Two-Step Cascade Reaction". . p. 2647 - 2652. Retrieved 2016/06/09.
• 2、 Pou, Ana,Moyano, Albert. "Stereoselective organocatalytic approach to α,β-disubstituted- β-amino acids: A short enantioselective synthesis of cispentacin". . p. 3103 - 3111. Retrieved 2013/06/26.