1H-INDAZOLE-7-CARBOXYLIC ACID

Base Information

• Chemical Name: 1H-INDAZOLE-7-CARBOXYLIC ACID
• CAS No.: 677304-69-7
• Molecular Formula: C8H6N2O2
• Molecular Weight: 162.148
• Hs Code.: 29339980
• Mol file: 677304-69-7.mol

Synonyms:7-Carboxy-1H-indazole;

Chemical Property of 1H-INDAZOLE-7-CARBOXYLIC ACID

Chemical Property:

• Melting Point: ca 240℃
• Boiling Point: 443.7 °C at 760 mmHg
• PKA: 3.71±0.10(Predicted)
• Flash Point: 222.2 °C
• PSA: 65.98000
• Density: 1.506 g/cm³
• LogP: 1.26110
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

1H-indazole-7-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1H-indazole-7-carboxylic Acid is an inhibitor of nitric oxide synthases.

Technology Process of 1H-INDAZOLE-7-CARBOXYLIC ACID

There total 7 articles about 1H-INDAZOLE-7-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1H-indazole-7-carbonitrile (256228-64-5) → 1H-indazole-7-carboxylic acid (677304-69-7)

Guidance literature:

With hydrogenchloride; for 12h; Heating;

DOI:10.1016/j.bmc.2008.04.056

Reference yield: 94.0%

1H-indazole-7-carboxylic acid methyl ester (755752-82-0,952479-65-1) → 1H-indazole-7-carboxylic acid (677304-69-7)

Guidance literature:

With potassium hydroxide; In methanol; water; at 0 - 20 ℃; for 18h;

Reference yield: 94.0%

methyl 1H-indazole-7-carboxylate hydrochloride (677304-71-1) → 1H-indazole-7-carboxylic acid (677304-69-7)

Guidance literature:

methyl 1H-indazole-7-carboxylate hydrochloride; With potassium hydroxide; water; In methanol; at 0 - 20 ℃; for 18h;

With hydrogenchloride; In methanol; water; pH=5.5;

upstream raw materials:

1H-indazole-7-carboxylic acid methyl ester

methyl 2-amino-3-methylbenzoate

methyl 1H-indazole-7-carboxylate hydrochloride

1H-indazole-7-carbonitrile

Downstream raw materials:

1H-indazole-7-carboxamide

2-[4-((3S)-3-piperidinyl)phenyl]-2H-indazole-7-carboxamide p-toluenesulfonic acid salt

N‐tert‐butyl‐1H‐indazole‐7‐carboxamide

1H-indazole-7-carboxylic acid methyl ester

Refernces

• 1、 -. "SPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS". Page/Page column 27-28. . Retrieved 2008/12/06.
• 2、 -. "Compounds". Page/Page column 44. . Retrieved 2008/06/13.