2-Chloro-5-cyanopyrazine

Base Information

• Chemical Name: 2-Chloro-5-cyanopyrazine
• CAS No.: 36070-75-4
• Molecular Formula: C5H2ClN3
• Molecular Weight: 139.544
• Hs Code.: 2933990090
• Mol file: 36070-75-4.mol

Synonyms:Pyrazinecarbonitrile,5-chloro- (7CI,9CI);2-pyrazinecarbonitrile, 5-chloro-;5-Chloro-2-pyrazinecarbonitrile;5-chloropyrazine-2-carbonitrile;

Chemical Property of 2-Chloro-5-cyanopyrazine

Chemical Property:

• Vapor Pressure: 0.036mmHg at 25°C
• Melting Point: 44-45oC
• Refractive Index: 1.568
• Boiling Point: 241.552 °C at 760 mmHg
• PKA: -5.41±0.10(Predicted)
• Flash Point: 99.887 °C
• PSA: 49.57000
• Density: 1.43g/cm³
• LogP: 1.00168
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Chloropyrazine-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-5-cyanopyrazine

There total 4 articles about 2-Chloro-5-cyanopyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

5-chloro-pyrazine-2-carboxylic acid amide (21279-64-1) → 5-chloro-2-pyrazinecarbonitrile (36070-75-4)

Guidance literature:

With cyanogen chloride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.5b00678

Reference yield:

pyrazinamide (98-96-4) → 6-chloropyrazine-2-carbonitrile (6863-74-7) + 5-chloro-2-pyrazinecarbonitrile (36070-75-4) + 2-chloro-3-cyanopyrazine (55557-52-3)

Guidance literature:

pyrazinamide; With dihydrogen peroxide; acetic acid; at 90 ℃; for 6h;

With trichlorophosphate; at 90 ℃; for 1h; Further stages.;

DOI:10.1002/ardp.200700119

Reference yield:

2-pyrazinecarboxamide-4-oxide (768-36-5) → 2-pyrazine carbonitrile (19847-12-2) + 6-chloropyrazine-2-carbonitrile (6863-74-7) + 5-chloro-2-pyrazinecarbonitrile (36070-75-4) + 2-chloro-3-cyanopyrazine (55557-52-3)

Guidance literature:

With trichlorophosphate; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

upstream raw materials:

2-pyrazinecarboxamide-4-oxide

3-pyrazinecarbonitrile N-oxide

pyrazinamide

5-chloro-pyrazine-2-carboxylic acid amide

Downstream raw materials:

5-chloro-pyrazine-2-carboxylic acid amide

Refernces

• 1、 Zitko, Jan,Paterova, Pavla,Kubicek, Vladimir,Mandikova, Jana,Trejtnar, Frantisek,Kunes, Jiri,Dolezal, Martin. "Synthesis and antimycobacterial evaluation of pyrazinamide derivatives with benzylamino substitution". . p. 476 - 479. Retrieved 2013/02/23.
• 2、 Palek, Lukas,Dvorak, Jaroslav,Svobodova, Michaela,Buchta, Vladimir,Jampilek, Josef,Dolezal, Martin. "Synthesis, antimycobacterial and antifungal evaluation of 3-arylaminopyrazine-2,5-dicarbonitriles". . p. 61 - 65. Retrieved 2008/12/20.