5-Cyclohexyl-1H-pyrazol-3-amine

Base Information

• Chemical Name: 5-Cyclohexyl-1H-pyrazol-3-amine
• CAS No.: 81542-54-3
• Molecular Formula: C9H15N3
• Molecular Weight: 165.238
• Hs Code.: 2933199090
• Mol file: 81542-54-3.mol

Synonyms:3-Cyclohexyl-1H-pyrazol-5-amine;

Chemical Property of 5-Cyclohexyl-1H-pyrazol-3-amine

Chemical Property:

• Vapor Pressure: 4.93E-06mmHg at 25°C
• Refractive Index: 1.591
• Boiling Point: 381.9 °C at 760 mmHg
• Flash Point: 212.9 °C
• PSA: 55.43000
• Density: 1.143 g/cm³
• LogP: 1.96970
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-Cyclohexyl-1H-pyrazol-3-ylamine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Cyclohexyl-1H-pyrazol-3-amine

There total 6 articles about 5-Cyclohexyl-1H-pyrazol-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-cyclohexyl-3-oxopropanenitrile (62455-70-3) → 3-cyclohexyl-1H-pyrazol-5-amine (81542-54-3)

Guidance literature:

With hydrazine hydrate; acetic acid; In ethanol; at 80 ℃; for 2h; Inert atmosphere;

Reference yield: 85.0%

→ 3-cyclohexyl-1H-pyrazol-5-amine (81542-54-3)

Guidance literature:

With hydrazine hydrate; In ethanol; for 18h; Reflux;

Reference yield: 61.0%

3-cyclohexyl-3-oxopropanenitrile (62455-70-3) → 5-cyclohexyl-3-amino-1H-pyrazole (81542-54-3)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2.5h; Reflux;

upstream raw materials:

3-cyclohexyl-3-oxopropanenitrile

methyl cyclohexylcarboxylate

ethyl cyclohexanecarboxylate

Downstream raw materials:

2,6-dicyclohexyl-6,7-dihydro-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione

Refernces

• 1、 -. "5- OR 7-AZAINDAZOLES AS BETA-LACTAMASE INHIBITORS". Page/Page column 41; 43; 44. . Retrieved 2020/09/19.
• 2、 -. "AURORA KINASE INHIBITORS". Paragraph 0266. . Retrieved 2014/12/12.