1-(5-BROMO-2-FLUOROPHENYL)ETHANONE

Base Information

• Chemical Name: 1-(5-BROMO-2-FLUOROPHENYL)ETHANONE
• CAS No.: 198477-89-3
• Molecular Formula: C8H6BrFO
• Molecular Weight: 217.037
• Hs Code.: 2914700090
• Mol file: 198477-89-3.mol

Synonyms:1-(5-Bromo-2-fluorophenyl)ethanone;

Chemical Property of 1-(5-BROMO-2-FLUOROPHENYL)ETHANONE

Chemical Property:

• Vapor Pressure: 0.021mmHg at 25°C
• Melting Point: 42 °C
• Refractive Index: 1.534
• Boiling Point: 251.017 °C at 760 mmHg
• Flash Point: 105.612 °C
• PSA: 17.07000
• Density: 1.535 g/cm³
• LogP: 2.79080
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%, ^*data from raw suppliers

5''-Bromo-2''-fluoroacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5'-Bromo-2'-fluoroacetophenone is an intermediate used in pharmaceuticals.

Technology Process of 1-(5-BROMO-2-FLUOROPHENYL)ETHANONE

There total 15 articles about 1-(5-BROMO-2-FLUOROPHENYL)ETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-bromo-2-fluoro-N-methoxy-N-methylbenzamide (910912-20-8) + methylmagnesium bromide (75-16-1) → 1-(5-bromo-2-fluorophenyl)ethan-1-one (198477-89-3)

Guidance literature:

5-bromo-2-fluoro-N-methoxy-N-methylbenzamide; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 0 ℃; for 6.5h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; diethyl ether; water; at 20 ℃; Cooling;

Reference yield: 92.0%

1-(5-bromo-2-fluorophenyl)ethan-1-ol (552331-15-4) → 1-(5-bromo-2-fluorophenyl)ethan-1-one (198477-89-3)

Guidance literature:

With chromium(VI) oxide; sulfuric acid; In water; acetone; at 0 - 20 ℃; for 14.5h;

Reference yield: 90.0%

→ 1-(5-bromo-2-fluorophenyl)ethan-1-one (198477-89-3)

Guidance literature:

With hydrogenchloride; In methanol; at 0 ℃; for 14h; Reflux;

upstream raw materials:

1-(5-bromo-2-fluorophenyl)ethan-1-ol

5-bromo-2-fluorobenzaldehyde

2-bromo-6-fluorobenzoic acid

methylmagnesium bromide

Downstream raw materials:

5-bromo-3-methyl-1H-indazole

(RS)-5-(5-bromo-2-fluorophenyl)-5-methyl-imidazolidine-2,4-dione

rac-5-(5-bromo-2-fluorophenyl)-5-methylmorpholin-3-one

rac-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid methyl ester

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS AND USES THEREOF". Paragraph 0960; 0963; 0964. . Retrieved 2019/04/25.