1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE

Base Information

• Chemical Name: 1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE
• CAS No.: 571189-49-6
• Molecular Formula: C10H16N4
• Molecular Weight: 192.264
• Hs Code.: 2933990090
• Mol file: 571189-49-6.mol

Synonyms:1-Methyl-4-(6-aminopyridin-3-yl)piperazine;5-(4-Methylpiperazin-1-yl)pyridin-2-amine;5-(4-Methylpiperazin-1-yl)pyridin-2-ylamine;

Chemical Property of 1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE

Chemical Property:

• Melting Point: 148 °C
• Boiling Point: 368.115 °C at 760 mmHg
• PKA: 7.41±0.42(Predicted)
• Flash Point: 176.43 °C
• PSA: 45.39000
• Density: 1.143 g/cm³
• LogP: 0.99970
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

5-(4-Methylpiperazin-1-yl)pyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-(4-Methylpiperazin-1-yl)pyridin-2-amine can be used for chemical mechanical planarization for tungsten-containing substrates.

Technology Process of 1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE

There total 11 articles about 1-METHYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-methyl-4-(6-nitro-pyridin-3-yl)-piperazine (657410-79-2) → 5-(4-methyl-piperazin-1-yl)pyridin-2-ylamine (571189-49-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

DOI:10.1021/acs.jmedchem.6b01670

Reference yield: 100.0%

→ 5-(4-methyl-piperazin-1-yl)pyridin-2-ylamine (571189-49-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

Reference yield: 92.0%

1-methyl-piperazine (109-01-3) + 2-amino-5-iodopyridine (20511-12-0) → 5-(4-methyl-piperazin-1-yl)pyridin-2-ylamine (571189-49-6)

Guidance literature:

With potassium phosphate; copper(l) iodide; ethylene glycol; In isopropyl alcohol; at 110 ℃; for 10h; Sealed tube;

DOI:10.1039/c7ra08482j

upstream raw materials:

1-methyl-4-(6-nitro-pyridin-3-yl)-piperazine

1-methyl-piperazine

5-bromo2-nitropyridine

2-amino-5-iodopyridine

Downstream raw materials:

6-tert-Butyl-8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(4-methyl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-2H-phthalazin-1-one

Refernces

• 1、 Chen, Lijuan,Chen, Yong,Deng, Dexin,Fu, Suhong,Guo, Yong,Hu, Mengshi,Li, Xiandeng,Liu, Kongjun,Peng, Bin,Si, Wenting,Tan, Yan,Tang, Minghai,Wang, Huan,Yang, Tao,Yang, Yingxue,Yang, Zhuang,Zhang, Chufeng. "Synthesis and biological evaluation of 6-(pyrimidin-4-yl)-1H-pyrazolo[4,3-b]pyridine derivatives as novel dual FLT3/CDK4 inhibitors". . . Retrieved 2022/02/17.
• 2、 Groendyke, Brian J.,Nabet, Behnam,Mohardt, Mikaela L.,Zhang, Haisheng,Peng, Ke,Koide, Eriko,Coffey, Calvin R.,Che, Jianwei,Scott, David A.,Bass, Adam J.,Gray, Nathanael S.. "Discovery of a Pyrimidothiazolodiazepinone as a Potent and Selective Focal Adhesion Kinase (FAK) Inhibitor". supporting information. p. 30 - 38. Retrieved 2021/01/11.