2-ACETAMIDOPYRIDINE-5-BORONIC ACID PINACOL ESTER, 97%

Base Information

• Chemical Name: 2-ACETAMIDOPYRIDINE-5-BORONIC ACID PINACOL ESTER, 97%
• CAS No.: 904326-87-0
• Molecular Formula: C13H19BN2O3
• Molecular Weight: 262.116
• Hs Code.: 2934999090
• Mol file: 904326-87-0.mol

Synonyms:N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]acetamide;N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetamide;N-[5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]acetamide;N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-yl]-acetamide;2-acetamidopyridine-5-boronic acid pinacol ester;ACETAMIDE,N-[5-[3-FLUORO-4-(METHYLSULFONYL)PHENYL]-4-METHYL-2-THIAZOLYL];

Chemical Property of 2-ACETAMIDOPYRIDINE-5-BORONIC ACID PINACOL ESTER, 97%

Chemical Property:

• Vapor Pressure: 4.31E-08mmHg at 25°C
• Melting Point: 130-134oC
• Boiling Point: 444.4oC at 760 mmHg
• PKA: 13.95±0.70(Predicted)
• Flash Point: 222.5ºC
• PSA: 60.45000
• Density: 1.11g/cm3
• LogP: 1.41220
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Acetamidopyridine-5-boronic acid pinacol ester ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Acetamidopyridine-5-boronic Acid Pinacol Ester, is a reagent used to synthesize new quinolinequinone derivatives as cytotoxic agents. In addition, novel benzoxazinyl-oxazolidinones are synthesized using this compound with application towards antibacterial agents.

Technology Process of 2-ACETAMIDOPYRIDINE-5-BORONIC ACID PINACOL ESTER, 97%

There total 7 articles about 2-ACETAMIDOPYRIDINE-5-BORONIC ACID PINACOL ESTER, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.1%

N-(5-bromopyridin-2-yl)acetamide (7169-97-3) + bis(pinacol)diborane (73183-34-3) → N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetamide (904326-87-0)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 100 ℃; Inert atmosphere; Industrial scale;

Reference yield: 82.96%

N-(5-bromo-6-methyl-pyridin-2-yl)-acetamide (142404-84-0) + bis(pinacol)diborane (73183-34-3) → N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetamide (904326-87-0)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 120 ℃; for 3h; Inert atmosphere;

Reference yield: 63.1%

2-aminopyridine-5-boronic acid pinacol ester (827614-64-2) + acetic anhydride (108-24-7) → N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetamide (904326-87-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃;

upstream raw materials:

N-(5-bromopyridin-2-yl)acetamide

bis(pinacol)diborane

2-aminopyridine-5-boronic acid pinacol ester

acetic anhydride

Downstream raw materials:

N-(5-(7-chloro-3-(2-chlorobenzyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)pyridin-2-yl)acetamide

5-(2-(2,8-dimethyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)phenyl)-N-methylpicolinamide

N-(5-(2-(2,8-dimethyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)phenyl)pyridin-2-yl)acetamide

N-(5-(3-(2,8-dimethyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)phenyl)pyridin-2-yl)acetamide

Refernces

• 1、 -. "A universal acetyl-aminopyridine boric acid frequency alcohol ester preparation method". Paragraph 0031; 0032. . Retrieved 2017/08/25.
• 2、 -. "THREE-RING PI3K AND/OR MTOR INHIBITOR". Paragraph 0263; 0264; 0265. . Retrieved 2015/06/24.