5,7-Dichloroquinoline

Base Information

• Chemical Name: 5,7-Dichloroquinoline
• CAS No.: 4964-77-6
• Molecular Formula: C9H5Cl2N
• Molecular Weight: 198.051
• Hs Code.: 2933499090
• Mol file: 4964-77-6.mol

Synonyms:5,7-Dichloroquinoline

Chemical Property of 5,7-Dichloroquinoline

Chemical Property:

• Melting Point: 116-117 °C
• Boiling Point: 308.327 °C at 760 mmHg
• PKA: 2.33±0.26(Predicted)
• Flash Point: 169.116 °C
• PSA: 12.89000
• Density: 1.408 g/cm³
• LogP: 3.54160
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

5,7-Dichloroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,7-Dichloroquinoline

There total 3 articles about 5,7-Dichloroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) + 3,5-Dichloroaniline (626-43-7) → 5,7-Dichloroquinoline (4964-77-6)

Guidance literature:

With sulfuric acid; sodium iodide; at 110 - 150 ℃; for 0.75h;

DOI:10.1002/anie.201305615

Reference yield: 38.0%

3,5-Dichloroaniline (626-43-7) + acrolein (107-02-8,25068-14-8) → 5,7-Dichloroquinoline (4964-77-6)

Guidance literature:

With hydrogenchloride; In water; toluene; Reflux;

DOI:10.1016/j.tetlet.2010.05.058

Reference yield:

5,7-dibromo-8-aminoquinoline (36107-02-5) → 5,7-Dichloroquinoline (4964-77-6)

Guidance literature:

With hydrogenchloride; hypophosphoric acid; sodium nitrite;

DOI:10.1021/ja01132a001

upstream raw materials:

5,7-dibromo-8-aminoquinoline

glycerol

3,5-Dichloroaniline

acrolein

Downstream raw materials:

5,7-dichloro-8-nitro-quinoline

7-chloro-5-methoxyquinoline

C₉H₆ClNO

Refernces

• 1、 Li, Jianke,Kung, Daniel W.,Griffith, David A.. "Synthesis of 5-hydroxyquinolines". scheme or table. p. 3876 - 3878. Retrieved 2010/08/19.