trans-3-(2,3,4-Trimethoxyphenyl)-2-propenoic acid

Base Information

• Chemical Name: trans-3-(2,3,4-Trimethoxyphenyl)-2-propenoic acid
• CAS No.: 116406-19-0
• Molecular Formula: C12H14O5
• Molecular Weight: 238.24
• Mol file: 116406-19-0.mol

Synonyms:2-Propenoicacid, 3-(2,3,4-trimethoxyphenyl)-, (E)-;trans-3-(2,3,4-Trimethoxyphenyl)-2-propenoic acid;

Chemical Property of trans-3-(2,3,4-Trimethoxyphenyl)-2-propenoic acid

Chemical Property:

• Melting Point: 172-173 °C
• Boiling Point: 392.2 °C at 760 mmHg
• Flash Point: 149.6 °C
• PSA: 64.99000
• Density: 1.209 g/cm³
• LogP: 1.81020

Purity/Quality:

98%min ^*data from raw suppliers

trans-2,3,4-Trimethoxycinnamic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of trans-3-(2,3,4-Trimethoxyphenyl)-2-propenoic acid

There total 7 articles about trans-3-(2,3,4-Trimethoxyphenyl)-2-propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

malonic acid (141-82-2) + 2,3,4-trimethoxybenzaldehyde (2103-57-3) → trans-2,3,4-trimethoxycinnamic acid (116406-19-0)

Guidance literature:

With piperidine; pyridine; at 115 ℃; for 6h;

DOI:10.1002/ejoc.202101508

Reference yield: 48.0%

(carbethoxymethyl)triphenylphosphonium bromide (1530-45-6) + 2,3,4-trimethoxybenzaldehyde (2103-57-3) → trans-2,3,4-trimethoxycinnamic acid (116406-19-0)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 16h;

DOI:10.1016/j.bmc.2006.09.034

Reference yield:

2,3,4-trimethoxy-trans-cinnamic acid ethyl ester (108125-64-0) → trans-2,3,4-trimethoxycinnamic acid (116406-19-0)

Guidance literature:

With potassium hydroxide; In ethanol; water;

upstream raw materials:

hydrangetin

dimethyl sulfate

(Z)-3-(2,3,4-trimethoxyphenyl)acrylic acid

malonic acid

Downstream raw materials:

3-(2,3,4-trimethoxy-phenyl)-propionic acid

(E)-N-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(2,3,4-trimethoxy-phenyl)-acrylamide

(E)-N-(6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(2,3,4-trimethoxy-phenyl)-acrylamide

(E)-1,3-Diethyl-8-(2,3,4-trimethoxystyryl)xanthine

Refernces

• 1、 Chen, Lingfeng,Jin, Yiyi,Chen, Hongjin,Sun, Chuchu,Fu, Weitao,Zheng, Lulu,Lu, Min,Chen, Pengqin,Chen, Gaozhi,Zhang, Yali,Liu, Zhiguo,Wang, Yi,Song, Zengqiang,Liang, Guang. "Discovery of caffeic acid phenethyl ester derivatives as novel myeloid differentiation protein 2 inhibitors for treatment of acute lung injury". . p. 361 - 375. Retrieved 2017/12/07.
• 2、 Srivastava, Vandana,Darokar, Mahendra P.,Fatima, Atiya,Kumar,Chowdhury, Chinmay,Saxena, Hari Om,Dwivedi, Gaurav R.,Shrivastava, Kunal,Gupta, Vivek,Chattopadhyay,Luqman, Suaib,Gupta,Negi, Arvind S.,Khanuja, Suman P.S.. "Synthesis of diverse analogues of Oenostacin and their antibacterial activities". . p. 518 - 525. Retrieved 2008/03/12.