5-CHLORO-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID

Base Information

• Chemical Name: 5-CHLORO-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID
• CAS No.: 21733-03-9
• Molecular Formula: C₃H₂ClN₃O₂
• Molecular Weight: 147.521
• Hs Code.: 2933990090
• Mol file: 21733-03-9.mol

Synonyms:5-Chloro-1H-1,2,4-triazole-3-carboxylic acid;

Chemical Property of 5-CHLORO-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID

Chemical Property:

• Boiling Point: 483.7 °C at 760 mmHg
• PKA: 2.92±0.10(Predicted)
• Flash Point: 246.4 °C
• PSA: 78.87000
• Density: 1.874 g/cm³
• LogP: 0.15630

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-1H-1,2,4-triazole-3-carboxylic acidN-methylmethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CHLORO-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID

There total 1 articles about 5-CHLORO-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

5-amino-1H-[1,2,4]triazole-3-carboxylic acid (3641-13-2) → C3H2ClN3O2 (21733-03-9)

Guidance literature:

5-amino-1H-[1,2,4]triazole-3-carboxylic acid; With sodium nitrite;

With hydrogenchloride;

DOI:10.1134/S1068162013010056

Reference yield: 83.0%

methanol (67-56-1) + C3H2ClN3O2 (21733-03-9) → methyl 5-chloro-1,2,4-triazole-3-carboxylate (21733-05-1)

Guidance literature:

With thionyl chloride; at 10 - 20 ℃;

DOI:10.1134/S1068162013010056

upstream raw materials:

5-amino-1H-[1,2,4]triazole-3-carboxylic acid

Downstream raw materials:

methyl 5-chloro-1,2,4-triazole-3-carboxylate

Refernces