2-Bromo-5-iodothiazole

Base Information

• Chemical Name: 2-Bromo-5-iodothiazole
• CAS No.: 108306-63-4
• Molecular Formula: C₃HBrINS
• Molecular Weight: 289.922
• Hs Code.: 2934100090
• European Community (EC) Number: 962-285-6
• DSSTox Substance ID: DTXSID50546084
• Nikkaji Number: J2.328.878H
• Wikidata: Q82423786
• Mol file: 108306-63-4.mol

Synonyms:2-BROMO-5-IODOTHIAZOLE;108306-63-4;2-bromo-5-iodo-1,3-thiazole;MFCD09999190;C3HBrINS;THIAZOLE,2-BROMO-5-IODO-;SCHEMBL23396003;DTXSID50546084;AKOS015834937;SY345913;CS-0130732;F16091;EN300-1239478;A895281

Chemical Property of 2-Bromo-5-iodothiazole

Chemical Property:

• Vapor Pressure: 0.011mmHg at 25°C
• Refractive Index: 1.714
• Boiling Point: 270.59 °C at 760 mmHg
• Flash Point: 117.449 °C
• PSA: 41.13000
• Density: 2.626 g/cm³
• LogP: 2.51020
• Storage Temp.: 2-8°C
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 288.80578
• Heavy Atom Count: 7
• Complexity: 72

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-5-iodothiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(SC(=N1)Br)I

Technology Process of 2-Bromo-5-iodothiazole

There total 3 articles about 2-Bromo-5-iodothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-bromo-1,3-thiazole (3034-53-5,215777-74-5) → 2-bromo-5-iodo-thiazole (108306-63-4)

Guidance literature:

2-bromo-1,3-thiazole; In tetrahydrofuran; at 25 ℃; for 0.333333h;

With iodine; In tetrahydrofuran; at 0 - 25 ℃; Further stages.;

DOI:10.1002/anie.200701984

Reference yield: 84.0%

→ 2-bromo-5-iodo-thiazole (108306-63-4)

Guidance literature:

Reference yield:

2-(trimethylsilyl)thiazole (79265-30-8) → 5-Iodothiazole (108306-61-2) + 2-bromo-5-iodo-thiazole (108306-63-4) + 2,5-diiodo-1,3-thiazole (108306-62-3)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1055/s-1986-31766

upstream raw materials:

2-(trimethylsilyl)thiazole

2-bromo-1,3-thiazole

Refernces

• 1、 -. "BISAMID-ZINKBASEN". Page/Page column 7-8. . Retrieved 2010/07/04.
• 2、 Dondoni, A.,Mastellari, A. R.,Medici, A.,Negrini, E.,Pedrini, P.. "Synthesis of Stannylthiazoles and Mixed Stannylsilylthiazoles and their Use for a Convenient Preparation of Mono- and Bis-halothiazoles". . p. 757 - 760. Retrieved 2007/10/02.