Methyl2-(2-ethynylphenyl)acetate

Base Information

• Chemical Name: Methyl2-(2-ethynylphenyl)acetate
• CAS No.: 637348-19-7
• Molecular Formula: C11H10O2
• Molecular Weight: 174.199
• Mol file: 637348-19-7.mol

Synonyms:Methyl (2-ethynylphenyl)acetate;benzeneacetic acid, 2-ethynyl-, methyl ester;(2-Ethynylphenyl)acetic acid methyl ester;

Chemical Property of Methyl2-(2-ethynylphenyl)acetate

Chemical Property:

• Vapor Pressure: 0.0133mmHg at 25°C
• Refractive Index: 1.531
• Boiling Point: 259 °C at 760 mmHg
• Flash Point: 101.9 °C
• PSA: 26.30000
• Density: 1.08 g/cm³
• LogP: 1.38340

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-(2-ethynylphenyl)acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl2-(2-ethynylphenyl)acetate

There total 7 articles about Methyl2-(2-ethynylphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(2-trimethylsilanylethynyl-phenyl)-acetic acid methyl ester (799804-49-2) → (2-ethynylphenyl)acetic acid methyl ester (637348-19-7)

Guidance literature:

With potassium carbonate; In methanol; ethanol;

DOI:10.1016/j.tet.2007.07.066

Reference yield: 85.0%

methyl (2-iodophenyl)acetate (66370-75-0) + trimethylsilylacetylene (1066-54-2) → (2-ethynylphenyl)acetic acid methyl ester (637348-19-7)

Guidance literature:

methyl (2-iodophenyl)acetate; trimethylsilylacetylene; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide;

With potassium fluoride; 18-crown-6 ether;

DOI:10.1021/ol1010483

Reference yield: 66.0%

methyl 2-(2-(3-hydroxy-3-methylbut-1-ynyl)phenyl)acetate (1160367-50-9) → (2-ethynylphenyl)acetic acid methyl ester (637348-19-7)

Guidance literature:

With sodium hydride; In toluene; mineral oil; for 0.5h; Reflux;

DOI:10.1002/adsc.200800249

upstream raw materials:

(2-trimethylsilanylethynyl-phenyl)-acetic acid methyl ester

methyl (2-iodophenyl)acetate

2-(2-iodophenyl)acetonitrile

2-(chloromethyl)iodobenzene

Downstream raw materials:

[2-(2-amino-phenylethynyl)-phenyl]-acetic acid methyl ester

methyl 2-diazo-2-(2-ethynylphenyl)acetate

methyl 2-(2-((2-((4-(4-((tert-butoxycarbonyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate

C₃₂H₃₂F₄N₄O₄

Refernces

• 1、 -. "VEGFR3 INHIBITORS". Page/Page column 75; 76. . Retrieved 2014/03/22.
• 2、 -. "FAK INHIBITORS". Page/Page column 56; 57. . Retrieved 2012/09/10.