5-FLUORO-6-METHOXY-PYRIDIN-3-YLAMINE

Base Information

• Chemical Name: 5-FLUORO-6-METHOXY-PYRIDIN-3-YLAMINE
• CAS No.: 886372-63-0
• Molecular Formula: C6H7FN2O
• Molecular Weight: 142.133
• Hs Code.: 2933399990
• Mol file: 886372-63-0.mol

Synonyms:QC-5174;3-AMINO-5-FLUORO-6-METHOXYPYRIDINE;

Chemical Property of 5-FLUORO-6-METHOXY-PYRIDIN-3-YLAMINE

Chemical Property:

• Vapor Pressure: 0.017mmHg at 25°C
• Boiling Point: 255.068oC at 760 mmHg
• PKA: 2.16±0.10(Predicted)
• Flash Point: 108.062oC
• PSA: 48.14000
• Density: 1.256g/cm3
• LogP: 1.39270
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-fluoro-6-methoxypyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-FLUORO-6-METHOXY-PYRIDIN-3-YLAMINE

There total 1 articles about 5-FLUORO-6-METHOXY-PYRIDIN-3-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid (82671-06-5) → 5-fluoro-6-methoxypyridin-3-ylamine (886372-63-0)

Guidance literature:

Multi-step reaction with 6 steps

1: hydrogenchloride / water / 2 h / 70 °C

2: methanol / 1 h / 20 °C

3: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid / N,N-dimethyl-formamide / 4 h / 100 °C

4: potassium hydroxide / methanol / 20 °C

5: triethylamine; diphenyl phosphoryl azide / toluene / 3 h / 110 °C

6: trifluoroacetic acid / 2 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid; diphenyl phosphoryl azide; triethylamine; trifluoroacetic acid; potassium hydroxide; In methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield: 100.0%

5-fluoro-6-methoxypyridin-3-ylamine (886372-63-0) + Benzoyl isothiocyanate (532-55-8) → N-((5-fluoro-6-methoxypyridin-3-yl)carbamothioyl)benzamide

Guidance literature:

In acetone; at 20 ℃; for 3h;

Reference yield: 90.0%

5-fluoro-6-methoxypyridin-3-ylamine (886372-63-0) + tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(6-methoxypyridin-3-ylamino)pyridin-3-yl)methyl)piperazine-1-carboxylate (1379860-81-7) → tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)methyl)piperazine-1-carboxylate (1253569-15-1)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -10 - -5 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm300846z

upstream raw materials:

2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid

Downstream raw materials:

4-(2-(5-fluoro-6-methoxypyridin-3-ylamino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

4-(5-chloro-2-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-2,2,2-trifluoroethanol

(R)-4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Refernces