5,8-Dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-amine

Base Information

• Chemical Name: 5,8-Dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-amine
• CAS No.: 219715-62-5
• Molecular Formula: C7H9N5O2
• Molecular Weight: 195.181
• Hs Code.: 2933990090
• European Community (EC) Number: 875-177-8
• UNII: 0129526470
• DSSTox Substance ID: DTXSID70466114
• Nikkaji Number: J2.121.125G
• Wikidata: Q27247522
• Mol file: 219715-62-5.mol

Synonyms:219715-62-5;5,8-Dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-amine;2-Amino-5,8-Dimethoxy-[1,2,4]Triazolo[1,5-C]Pyrimidine;[1,2,4]Triazolo[1,5-c]pyrimidin-2-amine, 5,8-dimethoxy-;5,8-Dimethoxy(1,2,4)triazolo(1,5-C)pyrimidin-2-amine;2-Amino-5,8-dimethoxy-(1,2,4)triazolo(1,5-C)pyrimidine;(1,2,4)Triazolo(1,5-C)pyrimidin-2-amine, 5,8-dimethoxy-;5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amine;2-Amino-5,8-dimethoxy(1,2,4)triazolo[1,5-c]pyrimidine;2-amino-5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidine;SCHEMBL841314;AMY3496;DTXSID70466114;DBJPBHJHAPAUQU-UHFFFAOYSA-N;BCP11311;MFCD17168561;AKOS015999945;CS-W006757;UNII-0129526470;AC-27550;AS-19932;A4709;BB 0262089;FT-0688434;D70654;EN300-3509381;Q27247522;2-amino-5,8-dimethoxy[1,2,4]triazolo[l,5-c]pyrimidine;2-amino-5,8-dimethoxy[1,2,4]-triazolo[1,5-c]pyrimidine;5,8-dimethoxy[1,2,4]triazolo-[1,5-c]pyrimidine-2-ylamine;5 pound not8-Dimethoxy-[1 pound not2 pound not4]triazolo[1 pound not5-c]pyrimidin-2-amine

Chemical Property of 5,8-Dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-amine

Chemical Property:

• Melting Point: 201-203 °C
• PKA: 2.66±0.30(Predicted)
• PSA: 88.29000
• Density: 1.61 g/cm³
• LogP: -0.34620
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 195.07562455
• Heavy Atom Count: 14
• Complexity: 205

Purity/Quality:

99.9% ^*data from raw suppliers

5,8-Dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CN=C(N2C1=NC(=N2)N)OC
• Uses: 5,8-Dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amine is an intermediate of Penoxsulam(P274000), which is an acetolactate synthase inhibitor herbicide developed for controlling grasses, sedges, and broadleaf weeds in rice culture.

Technology Process of 5,8-Dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-amine

There total 16 articles about 5,8-Dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.7%

→ 2-amino-5,8-dimethoxy[1,2,4]triazolo-[1,5-c]pyrimidine (219715-62-5)

Guidance literature:

Reference yield: 92.8%

3-amino-5,8-dimethoxy[1,2,4]triazolo[4,3-c]pyrimidine → 2-amino-5,8-dimethoxy[1,2,4]triazolo-[1,5-c]pyrimidine (219715-62-5)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 3h;

Reference yield: 91.2%

4-[4-(2,5-dimethoxypyrimidinyl)] (1350919-13-9) → 2-amino-5,8-dimethoxy[1,2,4]triazolo-[1,5-c]pyrimidine (219715-62-5)

Guidance literature:

With hydroxylamine hydrochloride; sodium methylate; triethylamine; In 1,4-dioxane; methanol; at 20 - 30 ℃;

upstream raw materials:

bromocyane

2-Chloro-4-hydrazino-5-methoxy-pyrimidine

3-amino-8-methoxy-5-methylthio-1,2,4-triazolo[4,3-c]pyrimidine hydrobromide

sodium methylate

Downstream raw materials:

2,6-dimethoxy-N-(5,8-dimethoxy-1,2,4-triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide

2-ethoxy-6-trifluoromethyl-N-(5,8-dimethoxy-1,2,4-triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide

2-methoxy-6-trifluoromethyl-N-(5,8-dimethoxy-1,2,4-triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide

2-(2-fluoroethoxy)-6-trifluoromethyl-N-(5,8-dimethoxy-1,2,4-triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide

Refernces

• 1、 -. "2-amino -5,8-disubstituted [1, 2, 4] triazolo [1,5-c] pyrimidine method for synthesizing environmental protection". Paragraph 0021; 0022; 0024. . Retrieved 2017/03/08.
• 2、 -. "PROCESS FOR THE PREPARATION OF 2-AMINO-5,8-DIMETHOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE FROM 4-CHLORO-2,5-DIMETHOXYPYRIMIDINE". . . Retrieved 2014/04/03.