Technology Process of Carbamicacid, N-[(1R)-2-methyl-1-[[(phenylmethyl)amino]carbonyl]propyl]-,1,1-dimethylethyl ester
There total 5 articles about Carbamicacid, N-[(1R)-2-methyl-1-[[(phenylmethyl)amino]carbonyl]propyl]-,1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Boc-D-Val-OH;
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate;
In
dichloromethane;
for 0.0833333h;
benzylamine;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
for 12h;
Further stages.;
DOI:10.1055/s-2007-965897
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water / 18 h / 0 - 20 °C
1.2: pH 2
2.1: 4-methyl-morpholine / tetrahydrofuran / -78 °C / Inert atmosphere
2.2: -78 °C / Inert atmosphere
3.1: tetrahydrofuran / 1.5 h / -78 - 20 °C / Inert atmosphere
With
4-methyl-morpholine; sodium hydroxide;
In
tetrahydrofuran; water;
DOI:10.1021/jm2004305
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water / 18 h / 0 - 20 °C
1.2: pH 2
2.1: 4-methyl-morpholine / tetrahydrofuran / -78 °C / Inert atmosphere
2.2: -78 °C / Inert atmosphere
3.1: tetrahydrofuran / 1.5 h / -78 - 20 °C / Inert atmosphere
With
4-methyl-morpholine; sodium hydroxide;
In
tetrahydrofuran; water;
DOI:10.1021/jm2004305
