7-Bromo-2-methylquinoline

Base Information

• Chemical Name: 7-Bromo-2-methylquinoline
• CAS No.: 4965-34-8
• Molecular Formula: C10H8BrN
• Molecular Weight: 222.084
• Hs Code.: 2933499090
• Mol file: 4965-34-8.mol

Synonyms:Quinoline, 7-bromo-2-methyl-;

Chemical Property of 7-Bromo-2-methylquinoline

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Melting Point: 77-79 °C
• Refractive Index: 1.654
• Boiling Point: 299.68 °C at 760 mmHg
• PKA: 4.25±0.50(Predicted)
• Flash Point: 135.042 °C
• PSA: 12.89000
• Density: 1.488 g/cm³
• LogP: 3.30570
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Bromo-2-methylquinoline ^*data from reagent suppliers

Safty Information:

• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Bromo-2-methylquinoline

There total 1 articles about 7-Bromo-2-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

m-Bromoaniline (591-19-5) + paracetaldehyde (123-63-7) → 2-methyl-7-bromo-quinoline (4965-34-8) + 5-bromo-2-methylquinoline (54408-52-5)

Guidance literature:

m-Bromoaniline; paracetaldehyde; With hydrogenchloride; In water; at 0 ℃; for 4h; Reflux;

With sodium hydroxide; In water; at 0 ℃;

Reference yield: 98.0%

2-methyl-7-bromo-quinoline (4965-34-8) → 2-methylquinolin-7-amine (64334-96-9)

Guidance literature:

With copper(I) oxide; ammonium hydroxide; N¹-(furan-2-ylmethyl)-N²-(2-methylnaphthalen-1-yl)oxalamide; potassium hydroxide; In ethanol; at 80 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.7b00901

Reference yield: 98.0%

2-methyl-7-bromo-quinoline (4965-34-8) → 7-bromoquinoline-2-carbaldehyde (904369-20-6)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; at 60 - 80 ℃; for 3h;

upstream raw materials:

m-Bromoaniline

paracetaldehyde

Downstream raw materials:

7-bromo-2-<2-(3-acetoxyphenyl)-(E)-ethenyl>quinoline

7-methoxy-2-methylquinoline

3-(7-bromo-2-quinolinylmethoxy)aniline

3-<2-(7-bromo-2-quinolinyl)ethynyl>phenol

Refernces