Technology Process of 2,6-DIFLUORO-N-(2-NITROPHENYL)BENZENAMINE
There total 1 articles about 2,6-DIFLUORO-N-(2-NITROPHENYL)BENZENAMINE which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,6-difluoroaniline;
With
sodium tert-amylate;
In
tetrahydrofuran;
at 0 - 10 ℃;
for 1.11667h;
Large scale reaction;
ortho-nitrofluorobenzene;
In
tetrahydrofuran;
at 9 - 15 ℃;
for 3h;
Concentration;
Time;
Thermodynamic data;
Large scale reaction;
DOI:10.1021/op100113j
- Guidance literature:
-
With
hydrogen;
nickel;
In
ethanol;
for 1h;
under 2068.65 Torr;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2 h / 45 °C / 3087.28 - 3604.44 Torr / Large scale reaction
2: tetrahydrofuran / 11.21 h / 20 - 30 °C / Large scale reaction
3: thionyl chloride; triethylamine / toluene / 3.58 h / -6 - 10 °C / Large scale reaction
4: sodium hypochlorite; tetrabutylammonium sulfate / dichloromethane; water / 1.37 h / 10 - 30 °C / Large scale reaction
5: water; sodium hydroxide / methanol / 1.5 h / 20 - 30 °C / Large scale reaction
6: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1.68 h / -5 - 26 °C / Large scale reaction
7: hydrogenchloride; water / tetrahydrofuran / 0.75 h / 52 - 58 °C / Large scale reaction
8: ethanol; water / 22 - 28 °C / Large scale reaction
With
hydrogenchloride; sodium hypochlorite; thionyl chloride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; water; hydrogen; tetrabutylammonium sulfate; triethylamine; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;
6: Mitsunobu reaction;
DOI:10.1021/op100113j
