6-bromonaphthalene-2-carbaldehyde

Base Information

• Chemical Name: 6-bromonaphthalene-2-carbaldehyde
• CAS No.: 170737-46-9
• Molecular Formula: C11H7BrO
• Molecular Weight: 235.08
• Hs Code.: 2913000090
• Mol file: 170737-46-9.mol

Synonyms:2-Naphthalenecarboxaldehyde, 6-bromo-;

Chemical Property of 6-bromonaphthalene-2-carbaldehyde

Chemical Property:

• Vapor Pressure: 3.05E-05mmHg at 25°C
• Melting Point: 125.0 to 130.0 °C
• Refractive Index: 1.7
• Boiling Point: 355.8 °C at 760 mmHg
• Flash Point: 125.9 °C
• PSA: 17.07000
• Density: 1.552 g/cm³
• LogP: 3.41480
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Bromo-2-naphthaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-bromonaphthalene-2-carbaldehyde

There total 7 articles about 6-bromonaphthalene-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(6-bromo-2-naphthy)methanol (100751-63-1) → 6-bromo-naphthalene-2-carboxaldehyde (170737-46-9)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2019.01.006

Reference yield: 95.0%

methyl 6-bromo-2-naphthoate (33626-98-1) → 6-bromo-naphthalene-2-carboxaldehyde (170737-46-9)

Guidance literature:

methyl 6-bromo-2-naphthoate; With diisobutylaluminium hydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With pyridinium chlorochromate; In dichloromethane; at 60 ℃; for 6h; Inert atmosphere;

Reference yield: 78.0%

2,6-dibromonaphthalene (13720-06-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-bromo-naphthalene-2-carboxaldehyde (170737-46-9)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/anie.201806742

upstream raw materials:

(6-bromo-2-naphthy)methanol

methyl 6-bromo-2-naphthoate

2-Bromo-6-methoxynaphthalene

6-bromo-2-naphthoic acid

Downstream raw materials:

(6-bromo-2-naphthy)methanol

6-(hydroxymethyl)-2-naphthonitrile

Refernces

• 1、 Ehrlich, Rachel S.,Shiao, Alexander L.,Li, Meihan,Teppang, Kristine L.,Jeoung, Kun Yong,Theodorakis, Emmanuel A.,Yang, Jerry. "Exploring the Effect of Aliphatic Substituents on Aryl Cyano Amides on Enhancement of Fluorescence upon Binding to Amyloid-β Aggregates". . p. 2946 - 2952. Retrieved 2021/08/06.
• 2、 Cai, Chunhui,Shen, Wei,Wang, Lei,Yi, Wenjun,Yu, Shian,Zhu, Qing,Zhu, Shen. "A dicyanoisophorone-based, near-infrared, lysosome-targeting pH sensor with an extremely large Stokes shift". . . Retrieved 2020/02/27.