2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine

Base Information

• Chemical Name: 2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine
• CAS No.: 1152475-50-7
• Molecular Formula: C₆H₃ClIN₃
• Molecular Weight: 279.467
• Mol file: 1152475-50-7.mol

Synonyms:2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine;5H-Pyrrolo[3,2-d]pyrimidine, 2-chloro-7-iodo-;2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine ISO 9001：2015 REACH

Chemical Property of 2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine

Chemical Property:

• PSA: 41.57000
• Density: 2.284 g/cm³
• LogP: 2.21590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine

There total 2 articles about 2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-chloro-5H-pyrrolo[3,2-d]pyrimidine? (1119280-66-8) → 2-chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine (1152475-50-7)

Guidance literature:

With iodine; sodium hydrogencarbonate; potassium iodide; In water; at 20 ℃; for 1h;

Reference yield:

2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine (63200-54-4) → 2-chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine (1152475-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium on activated charcoal; sodium hydrogencarbonate / ethanol / 2.5 h / 20 °C / 155.15 Torr

2: N-iodo-succinimide / N,N-dimethyl-formamide / 17 h / 0 - 20 °C

With N-iodo-succinimide; palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; In ethanol; N,N-dimethyl-formamide;

Reference yield: 94.0%

2-chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine (1152475-50-7) + methyl iodide (74-88-4) → 2-chloro-7-iodo-5-methyl-5H-pyrrolo[3,2-d]pyrimidine (1152475-62-1)

Guidance literature:

With tetrabutylammomium bromide; sodium hydroxide; In dichloromethane; at 20 ℃; for 16h;

upstream raw materials:

2-chloro-5H-pyrrolo[3,2-d]pyrimidine?

2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine

Downstream raw materials:

2-chloro-7-iodo-5-methyl-5H-pyrrolo[3,2-d]pyrimidine

Refernces

• 1、 -. "RORC2 INHIBITORS AND METHODS OF USE THEREOF". Paragraph 0221. . Retrieved 2016/03/22.