5,6-Dimethylpyridin-3-amine

Base Information

• Chemical Name: 5,6-Dimethylpyridin-3-amine
• CAS No.: 66093-07-0
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• Hs Code.: 2933399090
• European Community (EC) Number: 816-669-4
• DSSTox Substance ID: DTXSID90439502
• Wikidata: Q82255461
• Mol file: 66093-07-0.mol

Synonyms:5,6-dimethylpyridin-3-amine;66093-07-0;5-Amino-2,3-dimethylpyridine;5,6-DIMETHYL-PYRIDIN-3-YLAMINE;5,6-dimethyl-3-pyridinamine;5,6-DIMETHYL-(PYRIDIN-3-YL)AMINE;3-Pyridinamine, 5,6-dimethyl-;SCHEMBL94027;5-amino-3-methyl-2-picoline;2,3-Dimethylpyridine-5-amine;DTXSID90439502;FVIPZEZSEOZNTN-UHFFFAOYSA-N;(5,6-dimethyl-pyridin-3-yl)-amine;MFCD07783763;AKOS006284690;AB42833;DS-6393;AC-15002;AM20061424;CS-0130443;FT-0753574;D70114;EN300-122786;A903585;J-516673;Z1198174887

Chemical Property of 5,6-Dimethylpyridin-3-amine

Chemical Property:

• Vapor Pressure: 0.01mmHg at 25°C
• Refractive Index: 1.564
• Boiling Point: 263.803 °C at 760 mmHg
• PKA: 7.18±0.20(Predicted)
• Flash Point: 137.334 °C
• PSA: 38.91000
• Density: 1.04 g/cm³
• LogP: 1.86180
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 92.9

Purity/Quality:

98%min ^*data from raw suppliers

5-AMINO-2,3-DIMETHYLPYRIDINE 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CN=C1C)N

Technology Process of 5,6-Dimethylpyridin-3-amine

There total 3 articles about 5,6-Dimethylpyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,3-dimethyl-6-chloro-5-nitropyridine (65213-96-9) → 3-amino-5,6-dimethylpyridine (66093-07-0)

Guidance literature:

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; for 16h; under 2068.6 - 2327.2 Torr;

DOI:10.1021/jm00054a009

Reference yield:

3-nitro-5,6-dimethyl-2(1H)-pyridinone (98276-88-1) → 3-amino-5,6-dimethylpyridine (66093-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / POCl₃ / 6 h / 110 °C

2: 100 percent / H₂, Et₃N / 5percent Pd/C / methanol / 16 h / 2068.6 - 2327.2 Torr

With hydrogen; triethylamine; trichlorophosphate; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00054a009

Reference yield:

→ 3-amino-5,6-dimethylpyridine (66093-07-0)

Guidance literature:

2-Chlor-5,6-dimethyl-3-nitropyridin, Zn, H2SO4;

upstream raw materials:

2,3-dimethyl-6-chloro-5-nitropyridine

3-nitro-5,6-dimethyl-2(1H)-pyridinone

Downstream raw materials:

3-fluoro-5,6-dimethyl-pyridine-1-oxide

5,6-dimethyl-3-hydroxypyridine

Refernces

• 1、 -. "Hydroxylated inhibitors of HIV reverse transcriptase". . . Retrieved 2008/06/13.