(R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL

Base Information

• Chemical Name: (R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL
• CAS No.: 115290-81-8
• Molecular Formula: C10H15NO
• Molecular Weight: 165.235
• Hs Code.: 2922199090
• Mol file: 115290-81-8.mol

Synonyms:(R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL;(R)-3-(methylamino)-1-phenylpropanol;(1R)-(+)-3-(Methylamino)-1-phenylpropan-1-ol;(3R)-N-Methyl-3-hydroxy-3-phenylpropylamine;(R)-3-Hydroxy-N-methyl-3-phenylpropylamine;(R)-N-Methyl-3-hydroxy-3-phenylpropylamine;(R)-N-Methyl-3-phenyl-3-hydroxypropylamine;Atomoxetine Related Compound A (10 mg) (3-(Methylamino)-1-phenylpropan-1-ol)

Chemical Property of (R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL

Chemical Property:

• Vapor Pressure: 0.00126mmHg at 25°C
• Refractive Index: 1.53
• Boiling Point: 286.1 °C at 760 mmHg
• PKA: 14.24±0.20(Predicted)
• Flash Point: 114.8 °C
• PSA: 32.26000
• Density: 1.017 g/cm³
• LogP: 1.72040

Purity/Quality:

98%,99%, ^*data from raw suppliers

DestolylAtomoxetine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Destolyl Atomoxetine is a metabolitte of Atomoxetine (A791400), a norepinephrine reuptake inhibitor. Sitagliptin phosphate intermediate Destolyl Atomoxetine (Atomoxetine EP Impurity H) is a metabolitte of Atomoxetine (A791400), a norepinephrine reuptake inhibitor.

Technology Process of (R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL

There total 49 articles about (R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(R)-3-iodo-1-phenyl-1-propanol (127073-84-1) + methylamine (74-89-5) → (R)-N-methyl-3-phenyl-3-hydroxypropylamine (115290-81-8)

Guidance literature:

In tetrahydrofuran; water; at 23 ℃; for 2h;

DOI:10.1016/S0040-4039(01)93743-8

Reference yield: 93.0%

β-Methylaminoethyl phenyl ketone hydrochloride (2538-50-3) → (R)-N-methyl-3-phenyl-3-hydroxypropylamine (115290-81-8)

Guidance literature:

With Rh[((R,R)-BenzP*)(cod)]SbF₆; hydrogen; caesium carbonate; zinc(II) chloride; In methanol; at 20 ℃; for 48h; under 19001.3 Torr; enantioselective reaction; Autoclave;

DOI:10.1002/anie.201411384

Reference yield: 93.0%

(R)-(3-hydroxy-3-phenylpropyl)carbamic acid ethyl ester (502697-62-3) → (R)-N-methyl-3-phenyl-3-hydroxypropylamine (115290-81-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1016/j.tetasy.2005.04.002

upstream raw materials:

(1R)-3-chloro-1-phenylpropanol

methylamine

(R)-3-iodo-1-phenyl-1-propanol

(1R) 3-phenyl-3-hydroxypropyl methanesulfonate

Downstream raw materials:

(R)-tomoxetine

(R)-N-(3-hydroxy-3-phenylpropyl)-N-methylacetamide

(R)-fluoxetine

(R)-N-methyl-N-{3-phenyl-3-[4-trifluoromethyl]phenoxylpropyl}acetamide

Refernces

• 1、 -. "Method for synthesizing chiral secondary alcohol compound". Paragraph 0038-0043; 0114-0117. . Retrieved 2021/05/29.
• 2、 Wang, Shoulei,Rodríguez-Escrich, Carles,Fan, Xinyuan,Pericàs, Miquel A.. "A site isolation-enabled organocatalytic approach to enantiopure γ-amino alcohol drugs". supporting information. p. 3943 - 3946. Retrieved 2018/04/20.