Technology Process of 4-Bromo-5-methyl-1H-Indazole
There total 3 articles about 4-Bromo-5-methyl-1H-Indazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrazine hydrate;
In
tetrahydrofuran;
at 40 ℃;
for 2h;
Solvent;
Temperature;
- Guidance literature:
-
3-bromo-dimethylaniline;
With
tetrafluoroboric acid; sodium nitrite;
In
water;
at 0 ℃;
for 1h;
With
18-crown-6 ether; potassium acetate;
In
chloroform;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C
1.2: 1 h / 20 °C
2.1: potassium carbonate / 1,2-dimethoxyethane / 2 h / 40 °C
3.1: hydrazine hydrate / tetrahydrofuran / 2 h / 40 °C
With
hydrazine hydrate; potassium carbonate; lithium diisopropyl amide;
In
tetrahydrofuran; 1,2-dimethoxyethane;