2-(2,4-Dimethyl-thiazol-5-yl)-ethylamine

Base Information

• Chemical Name: 2-(2,4-Dimethyl-thiazol-5-yl)-ethylamine
• CAS No.: 142437-68-1
• Molecular Formula: C7H12N2S
• Molecular Weight: 156.252
• Hs Code.: 2934100090
• Mol file: 142437-68-1.mol

Synonyms:2-(2, 4-Dimethyl-1, 3-thiazol-5-yl)ethan-1-amine;

Chemical Property of 2-(2,4-Dimethyl-thiazol-5-yl)-ethylamine

Chemical Property:

• Vapor Pressure: 0.0139mmHg at 25°C
• Refractive Index: 1.557
• Boiling Point: 258.2 °C at 760 mmHg
• Flash Point: 110 °C
• PSA: 67.15000
• Density: 1.106 g/cm³
• LogP: 1.96140
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

2-(2,4-Dimethylthiazol-5-yl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2,4-Dimethyl-thiazol-5-yl)-ethylamine

There total 5 articles about 2-(2,4-Dimethyl-thiazol-5-yl)-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

tert-butyl [2-(2,4-dimethyl-1,3-thiazol-5-yl)ethyl]carbamate (911848-17-4) → 2-(2,4-dimethyl-thiazol-5-yl)-ethylamine (142437-68-1)

Guidance literature:

tert-butyl [2-(2,4-dimethyl-1,3-thiazol-5-yl)ethyl]carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With hydrogenchloride; In water; ethyl acetate;

With sodium hydroxide; In water; pH=12;

Reference yield:

(2,4-dimethyl-thiazol-5-yl)-acetonitrile (50382-35-9) → 2-(2,4-dimethyl-thiazol-5-yl)-ethylamine (142437-68-1)

Guidance literature:

With methanol; nickel; Hydrogenation;

DOI:10.1039/jr9470001400

Reference yield:

2-(2,4-dimethyl-thiazol-5-yl)-acetamide (61928-55-0) → 2-(2,4-dimethyl-thiazol-5-yl)-ethylamine (142437-68-1)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃

2: Raney nickel; methanol / Hydrogenation

With methanol; nickel; trichlorophosphate;

DOI:10.1039/jr9470001400

upstream raw materials:

(2,4-dimethyl-thiazol-5-yl)-acetonitrile

(2,4-dimethyl-1,3-thiazole-5-yl)acetic acid

2-(2,4-dimethyl-thiazol-5-yl)-acetamide

ethyl 2-(2,4-dimethylthiazol-5-yl)acetate

Refernces

• 1、 -. "New heterocyclylethylbenzamide derivatives". Page/Page column 25. . Retrieved 2008/06/13.