1-(1-Hydroxy-cyclopentyl)-ethanone

Base Information

• Chemical Name: 1-(1-Hydroxy-cyclopentyl)-ethanone
• CAS No.: 17160-89-3
• Molecular Formula: C7H12O2
• Molecular Weight: 128.171
• Hs Code.: 2914400090
• Mol file: 17160-89-3.mol

Synonyms:1-ACETYLCYCLOPENTANOL;1-Acetyl-1-hydroxycyclopentane;Methyl(1-hydroxycyclopentyl) ketone;

Chemical Property of 1-(1-Hydroxy-cyclopentyl)-ethanone

Chemical Property:

• Melting Point: 72-73 °C
• Boiling Point: 215 °C at 760 mmHg
• PKA: 13.28±0.20(Predicted)
• Flash Point: 85.8 °C
• PSA: 37.30000
• Density: 1.11g/cm³
• LogP: 0.88050

Purity/Quality:

98%min ^*data from raw suppliers

1-acetylcyclopentanol 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(1-Hydroxy-cyclopentyl)-ethanone

There total 15 articles about 1-(1-Hydroxy-cyclopentyl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1-ethynylcyclopentanol (17356-19-3) → 1-acetylcyclopentanol (17160-89-3)

Guidance literature:

With sulfuric acid; mercury(II) oxide; In water; acetone; at 60 ℃; for 3h; Inert atmosphere;

DOI:10.1002/jhet.3454

Reference yield: 14.0%

cyclopentanone (120-92-3) + acetonitrile (75-05-8,26809-02-9) → Cyclopentanol (96-41-3) + 1-acetylcyclopentanol (17160-89-3)

Guidance literature:

With tetraethylammonium tosylate; In ethanol; at 5 ℃; electroreduction (Sn-cathode);

DOI:10.1021/jo00052a036

Reference yield:

1-(1-hydroxy-ethyl)-cyclopentanol (16177-52-9) → 1-acetylcyclopentanol (17160-89-3)

Guidance literature:

With N-Bromosuccinimide; water; In 1,4-dioxane; for 2h; Ambient temperature;

DOI:10.1021/ja00522a060

upstream raw materials:

1-tetrahydropyran-2-yloxy-cyclopentanecarbonitrile

1-ethynylcyclopentanol

1-(1-hydroxy-ethyl)-cyclopentanol

2-diethylaminopropionitrile

Downstream raw materials:

2-hydroxy-2-methylcyclohexanone

3-(N-cyclohexylcarbamoyl)-4-methyl-1-oxaspiro[4.4]non-3-en-2-one

3-(N-cyclohexylcarbamoyl)-4-methyl-2-(N-methylimino)-1-oxaspiro[4.4]non-3-ene

Refernces

• 1、 Chenna Reddy,Patil, Vineetkumar B.,Nawaz Khan, Fazlur Rahman,Saravanan, Vadivelu. "Synthesis of Imidazo[1,2-a]pyridines and Imidazo[2,1-b]thiazoles Attached to a Cycloalkyl or Saturated Heterocycle Containing a Tertiary Hydroxy Substitution". . p. 1486 - 1497. Retrieved 2019/04/04.
• 2、 Jung, Jae-Kyu,Johnson, Benjamin R.,Duong, Tracy,Decaire, Marc,Uy, Jane,Gharbaoui, Tawfik,Boatman, P. Douglas,Sage, Carleton R.,Chen, Ruoping,Richman, Jeremy G.,Connolly, Daniel T.,Semple, Graeme. "Analogues of Acifran: Agonists of the high and low affinity niacin receptors, GPR109a and GPR109b". . p. 1445 - 1448. Retrieved 2007/10/03.