5-methoxy-6-methyl-2-aminoindan

Base Information

• Chemical Name: 5-methoxy-6-methyl-2-aminoindan
• CAS No.: 132980-16-6
• Molecular Formula: C11H15NO
• Molecular Weight: 177.2429
• Hs Code.: 2922199090
• Mol file: 132980-16-6.mol

Synonyms:5-methoxy-6-methyl-2-aminoindan;5-Methoxy-6-Methyl-2,3-dihydro-1H-inden-2-aMine

Chemical Property of 5-methoxy-6-methyl-2-aminoindan

Chemical Property:

• Vapor Pressure: 0.00258mmHg at 25°C
• Refractive Index: 1.556
• Boiling Point: 286.8 °C at 760 mmHg
• Flash Point: 129.3 °C
• PSA: 35.25000
• Density: 1.065g/cm³
• LogP: 2.12980

Purity/Quality:

99%, ^*data from raw suppliers

5-METHOXY-6-METHYL-2,3-DIHYDRO-1H-INDEN-2-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-methoxy-6-methyl-2-aminoindan

There total 10 articles about 5-methoxy-6-methyl-2-aminoindan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H15N3O → 5-methoxy-6-methyl-2-aminoindan (136468-19-4,132980-16-6)

Guidance literature:

With potassium hydroxide; In 5,5-dimethyl-1,3-cyclohexadiene; at 120 ℃; for 0.5h;

Reference yield:

2-(hydroxyimino)-5-methoxy-6-methyl-1-indanone (132980-21-3) → 5-methoxy-6-methyl-2-aminoindan (136468-19-4,132980-16-6)

Guidance literature:

With sulfuric acid; hydrogen; palladium on activated charcoal; In acetic acid; for 18h; under 3102.9 Torr;

DOI:10.1021/jm00109a020

Reference yield:

3-methoxy-4-methylbenzaldehyde (24973-22-6) → 5-methoxy-6-methyl-2-aminoindan (136468-19-4,132980-16-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 99.7 percent / piperidine, piridine / 5 h / Heating

2: 99.7 percent / H₂ / 10percent Pd-C / aq. ethanol / 6 h / 3102.9 Torr

3: oxalyl chloride, DMF / benzene / 4 h / Ambient temperature

4: SnCl₄ / CH₂Cl₂ / 1 h

5: 96.9 percent / isoamyl nitrite, concd. HCl / methanol / 0.75 h / 45 °C

6: concd. H₂SO₄, H₂ / 10percent Pd-C / acetic acid / 18 h / 3102.9 Torr

With piperidine; pyridine; hydrogenchloride; oxalyl dichloride; sulfuric acid; hydrogen; tin(IV) chloride; N,N-dimethyl-formamide; isopentyl nitrite; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetic acid; benzene;

DOI:10.1021/jm00109a020

upstream raw materials:

2-(hydroxyimino)-5-methoxy-6-methyl-1-indanone

3-methoxy-4-methylbenzaldehyde

3-(3-methoxy-4-methylphenyl)propanoic acid

5-methoxy-6-methyl-1-indanone

Refernces

• 1、 Johnson,Frescas,Oberlender,Nichols. "Synthesis and pharmacological examination of 1-(3-methoxy-4-methylphenyl)-2-aminopropane and 5-methoxy-6-methyl-2-aminoindan: Similarities to 3,4-(methylenedioxy)methamphetamine (MDMA)". . p. 1662 - 1668. Retrieved 2007/10/02.