7-Fluoro-4-Methyl Isatin

Base Information

• Chemical Name: 7-Fluoro-4-Methyl Isatin
• CAS No.: 749240-53-7
• Molecular Formula: C₉H₆FNO₂
• Molecular Weight: 179.151
• Mol file: 749240-53-7.mol

Synonyms:7-Fluoro-4-Methyl Isatin

Chemical Property of 7-Fluoro-4-Methyl Isatin

Chemical Property:

• PSA: 46.17000
• Density: 1.399g/cm³
• LogP: 1.40690

Purity/Quality:

98%min ^*data from raw suppliers

7-fluoro-4-methyl-2,3-dihydro-1H-indole-2,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Fluoro-4-Methyl Isatin

There total 3 articles about 7-Fluoro-4-Methyl Isatin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(2E)-N-(2-fluoro-5-methylphenyl)-2-(N-hydroxyimino)acetamide → 7-fluoro-4-methyl-1H-indole-2,3-dione (749240-53-7)

Guidance literature:

With sulfuric acid; at 20 - 70 ℃; for 2h;

Reference yield:

N-(2-fluoro-5-methylphenyl)-2-hydroxyiminoacetamide → 7-fluoro-4-methyl-1H-indole-2,3-dione (749240-53-7)

Guidance literature:

With sulfuric acid; In water; at 80 ℃; for 1h;

Reference yield:

3-amino-4-fluorotoluene (452-84-6) → 7-fluoro-4-methyl-1H-indole-2,3-dione (749240-53-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate / water / 1.5 h / Reflux

2: sulfuric acid / water / 1 h / 80 °C

With hydrogenchloride; sulfuric acid; hydroxylamine hydrochloride; sodium sulfate; In water;

upstream raw materials:

3-amino-4-fluorotoluene

Refernces

• 1、 -. "TETRAZOLINONE COMPOUND AND USE THEREOF". . . Retrieved 2015/11/16.