3-Aminoquinoxaline-2-carboxamide

Base Information

• Chemical Name: 3-Aminoquinoxaline-2-carboxamide
• CAS No.: 67568-30-3
• Molecular Formula: C9H8N4O
• Molecular Weight: 188.189
• Hs Code.: 2933990090
• Mol file: 67568-30-3.mol

Synonyms:Quinoxalinecarboxamide, 3-amino-;

Chemical Property of 3-Aminoquinoxaline-2-carboxamide

Chemical Property:

• Vapor Pressure: 9.88E-07mmHg at 25°C
• Refractive Index: 1.751
• Boiling Point: 403.8 °C at 760 mmHg
• Flash Point: 198 °C
• PSA: 94.89000
• Density: 1.436 g/cm³
• LogP: 1.59240
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

3-Aminoquinoxaline-2-carboxamide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Aminoquinoxaline-2-carboxamide

There total 12 articles about 3-Aminoquinoxaline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-amino-2-quinoxalinecarbonitrile (36597-16-7) → 2-Amino-3-carboxamidoquinoxaline (67568-30-3)

Guidance literature:

With potassium hydroxide; dihydrogen peroxide; In ethanol; at 40 ℃; for 2h;

DOI:10.1002/jhet.5570310506

Reference yield: 59.4%

2-Amino-3-carboxamidoquinoxaline 1,4-di-N-oxide (23280-20-8) → 2-Amino-3-carboxamidoquinoxaline (67568-30-3)

Guidance literature:

With sodium disulfite; In ethanol; at 20 - 25 ℃; for 72h;

DOI:10.1007/BF00766905

Reference yield:

methyl 3-chloroquinoxaline-2-carboxylate (1085940-92-6) → 2-Amino-3-carboxamidoquinoxaline (67568-30-3)

Guidance literature:

With ammonia; In water; at 60 ℃;

upstream raw materials:

ethyl 3-chloroquinoxaline-2-carboxylate

2-Amino-3-carboxamidoquinoxaline 1,4-di-N-oxide

3-amino-2-quinoxalinecarbonitrile

benzofurazan oxide

Downstream raw materials:

2-aminoquinoxaline-3-carboxylic acid

3-benzyl-2-isobutylbenzo[g]pteridin-4(3H)-one

3-benzyl-2-(1-bromo-2-methyl-propyl)-3H-benzo[g]pteridin-4-one

{3-[1-(3-Benzyl-4-oxo-3,4-dihydro-benzo[g]pteridin-2-yl)-2-methyl-propylamino]-propyl}-carbamic acid tert-butyl ester

Refernces

• 1、 -. "KINESIN INHIBITORS". Page/Page column 51. . Retrieved 2009/01/20.
• 2、 Monge,Palop,Pinol,Martinez-Crespo,Narro,Gonzalez,Sainz,Lopez De Cerain,Hamilton,Barker. "3-Amino-2-quinoxalinecarbonitrile. New fused quinoxalines with potential cytotoxic activity". . p. 1135 - 1139. Retrieved 2007/10/02.