[4-(4-Chlorophenyl)phenyl]methylamine hydrochloride

Base Information

• Chemical Name: [4-(4-Chlorophenyl)phenyl]methylamine hydrochloride
• CAS No.: 410077-96-2
• Molecular Formula: C₁₃H₁₂ClN*ClH
• Molecular Weight: 254.159
• Hs Code.: 2921499090
• ChEMBL ID: CHEMBL2403807
• DSSTox Substance ID: DTXSID50592107
• Mol file: 410077-96-2.mol

Synonyms:410077-96-2;[4-(4-chlorophenyl)phenyl]methylamine hydrochloride;(4'-Chloro-[1,1'-biphenyl]-4-yl)methanamine hydrochloride;4-(4-CHLOROPHENYL)BENZYLAMINE HCL;4-(4-Chlorophenyl)benzylamine hydrochloride;[4-(4-Chlorophenyl)phenyl]methylamine, HCl;[4-(4-chlorophenyl)phenyl]methanamine;hydrochloride;[4-(4-Chlorophenyl)Phenyl]MethylamineHydrochloride;4-(4-Chlorophenyl)Phenyl]Methylamine Hydrochloride;(4'-chlorobiphenyl-4-yl)methanamine hydrochloride;AR1997;SCHEMBL2069798;CHEMBL2403807;(4'-Chloro-[1,1'-biphenyl]-4-yl)methanaminehydrochloride;DTXSID50592107;PUSWBWIRYUMVRE-UHFFFAOYSA-N;AMY13642;MFCD02089424;AKOS015899102;SB81557;4-(4-chlorophenyl)phenylmethyl amine hcl;AS-45255;[4-(4-Chlorophenyl)phenyl]methylamine HCl;DB-070122;CS-0200174;A22096;(4'-Chlorophenyl-4-yl)methanamine hydrochloride;(4'-chlorobiphenyl-4-yl)methylamine hydrochloride;J-502754;(4'-Chloro[1,1'-biphenyl]-4-yl)methanamine hydrochloride, AldrichCPR;1-(4'-Chloro[1,1'-biphenyl]-4-yl)methanamine--hydrogen chloride (1/1)

Chemical Property of [4-(4-Chlorophenyl)phenyl]methylamine hydrochloride

Chemical Property:

• Boiling Point: 382.2 °C at 760 mmHg
• Flash Point: 185 °C
• PSA: 26.02000
• LogP: 4.96800
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 253.0425048
• Heavy Atom Count: 16
• Complexity: 179

Purity/Quality:

99% ^*data from raw suppliers

[4-(4-Chlorophenyl)phenyl]methylamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1CN)C2=CC=C(C=C2)Cl.Cl
• Uses: [4-(4-Chlorophenyl)phenyl]methylamine Hydrochloride can be used to treat bacterial infections.

Technology Process of [4-(4-Chlorophenyl)phenyl]methylamine hydrochloride

There total 2 articles about [4-(4-Chlorophenyl)phenyl]methylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4'-chloro-[1,1'-biphenyl]-4-yl)methanamine (15996-82-4) → (4′-chlorobiphenyl-4-yl)methylammonium chloride (410077-96-2)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; at 20 ℃; for 1h;

DOI:10.1021/jm4007092

Reference yield:

4-Bromobenzylamine (3959-07-7) + 4-Chlorophenylboronic acid (1679-18-1) → (4′-chlorobiphenyl-4-yl)methylammonium chloride (410077-96-2)

Guidance literature:

4-Bromobenzylamine; 4-Chlorophenylboronic acid; With potassium carbonate; In acetonitrile; for 0.25h; Reflux; Inert atmosphere;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetonitrile; Reflux; Inert atmosphere; Enzymatic reaction;

With hydrogenchloride; at 20 ℃; for 1h;

DOI:10.1021/jm500707r

upstream raw materials:

(4'-chloro-[1,1'-biphenyl]-4-yl)methanamine

4-Bromobenzylamine

4-Chlorophenylboronic acid

Refernces

• 1、 Lee, Hyosung,Park, Ki Duk,Yang, Xiao-Fang,Dustrude, Erik T.,Wilson, Sarah M.,Khanna, Rajesh,Kohn, Harold. "(Biphenyl-4-yl)methylammonium chlorides: Potent anticonvulsants that modulate Na+ currents". . p. 5931 - 5939. Retrieved 2013/08/23.