3-METHOXYPYRIDINE-4-BORONIC ACID

Base Information

• Chemical Name: 3-METHOXYPYRIDINE-4-BORONIC ACID
• CAS No.: 1008506-24-8
• Molecular Formula: C6H8BNO3
• Molecular Weight: 152.945
• Hs Code.: 2933399090
• Mol file: 1008506-24-8.mol

Synonyms:(3-Methoxy-4-pyridyl)boronic acid;3-Methoxypyridine-4-boronic acid;

Chemical Property of 3-METHOXYPYRIDINE-4-BORONIC ACID

Chemical Property:

• Appearance/Colour: off-white solid
• Boiling Point: 357 °C at 760 mmHg
• PKA: 7.62±0.58(Predicted)
• Flash Point: 169.7 °C
• PSA: 62.58000
• Density: 1.24 g/cm³
• LogP: -1.23000
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%min ^*data from raw suppliers

3-Methoxypyridine-4-boronicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-METHOXYPYRIDINE-4-BORONIC ACID

There total 2 articles about 3-METHOXYPYRIDINE-4-BORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxypyridine (7295-76-3,1232006-42-6) + Triisopropyl borate (5419-55-6) → 3‐methoxypyridin‐4‐ylboronic acid (1008506-24-8)

Guidance literature:

3-methoxypyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 1h;

Triisopropyl borate; In tetrahydrofuran; for 2h;

Reference yield:

→ 3‐methoxypyridin‐4‐ylboronic acid (1008506-24-8)

Guidance literature:

Reference yield: 90.0%

3‐methoxypyridin‐4‐ylboronic acid (1008506-24-8) + 3,5-dimethoxyphenyl 2,3,4,5,6-pentafluorobenzenesulfonate → 4-(3,5-dimethoxyphenyl)-3-methoxypyridine

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate monohydrate; In tert-butyl alcohol; at 28 ℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tetlet.2015.07.033

upstream raw materials:

3-methoxypyridine

Triisopropyl borate

Downstream raw materials:

6,7-dimethoxy-1-[4-(3-methoxypyridin-4-yl)benzyl]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

4-(4,4-dimethylcyclohex-1-en-1-yl)-5-(3-methoxy-pyridin-4-yl)-pyrimidin-2-amine

1-(3-{[4-(3-methoxypyridin-4-yl)-1,3,5-triazin-2-yl]amino}phenyl)methanesulfonamide

6,7-dimethoxy-1-[4-(3-methoxypyridin-4-yl)benzyl]-1,2,3,4-tetrahydroisoquinoline hydrochloride

Refernces

• 1、 -. "PHOSPHODIESTERASE 4 INHIBITORS". Page 83. . Retrieved 2008/06/13.