DL-Glutamic acid

Base Information

• Chemical Name: DL-Glutamic acid
• CAS No.: 56-86-0
• Molecular Formula: C5H9NO4
• Molecular Weight: 147.131
• Hs Code.: 2922421000
• European Community (EC) Number: 210-522-2
• NSC Number: 206301,620337,143503,77686,9967
• UNII: 61LJO5I15S
• DSSTox Substance ID: DTXSID0046987
• Nikkaji Number: J5.177B
• Wikidata: Q181136,Q27145702
• NCI Thesaurus Code: C81373
• Mol file: 56-86-0.mol

Synonyms:Aluminum L Glutamate;Aluminum L-Glutamate;D Glutamate;D-Glutamate;Glutamate;Glutamate, Potassium;Glutamic Acid;Glutamic Acid, (D)-Isomer;L Glutamate;L Glutamic Acid;L-Glutamate;L-Glutamate, Aluminum;L-Glutamic Acid;Potassium Glutamate

Chemical Property of DL-Glutamic acid

Chemical Property:

• Appearance/Colour: White cryst. powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 205 °C (dec.)(lit.)
• Refractive Index: 1.508
• Boiling Point: 333.783 °C at 760 mmHg
• Flash Point: 155.667 °C
• PSA: 100.62000
• Density: 1.41 g/cm³
• LogP: -0.03660
• Water Solubility.: 7.5 g/L (20℃)
• XLogP3: -3.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 147.05315777
• Heavy Atom Count: 10
• Complexity: 145

Purity/Quality:

min 99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: S24/25:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Biological Agents -> Amino Acids and Derivatives
• Canonical SMILES: C(CC(=O)O)C(C(=O)O)N
• Recent ClinicalTrials: Effects of Dietary Amino Acids on Serum and Macrophage Atherogenicity
• Biological Functions: Glutamic acid serves as a fundamental excitatory neurotransmitter in the central nervous system, playing a crucial role in cognitive and sensorimotor functions. It is essential for brain functions and homeostasis.
• Role in Plant Development: Glutamic acid contributes to the development of chlorophyll molecules and is involved in carbohydrate anabolism. It aids in the synthesis of growth materials akin to plant hormones, promoting plant growth and adapting to environmental conditions.
• Food Industry Importance: L-glutamic acid, a non-essential amino acid, is naturally present in various foods either in free form or bound with proteins. It is extracted from sources like wheat gluten, soybean meal, and casein, or produced through microbial fermentation. In the food industry, it serves as a flavor-enhancing additive, commonly known as monosodium glutamate (MSG), added to foods such as soups, meats, seasonings, snacks, and sauces for taste enhancement.
• Role as Precursor: L-glutamic acid acts as a precursor for the synthesis of proline, an essential amino acid crucial for collagen structure.
• Metabolism in Living Organisms: Being an amino acid, L-glutamic acid can be easily metabolized by living organisms in soil and plants.
• pH-sensitive Properties: Glutamic acid exhibits distinctive pH-sensitive properties, existing in different forms such as zwitterions, glutamate anions, and double-negative anions depending on the pH of the environment.

Technology Process of DL-Glutamic acid

There total 363 articles about DL-Glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-glutamic acid 5-(4-nitroanilide) (7300-59-6) → L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + 4-nitro-aniline (100-01-6,104810-17-5)

Guidance literature:

With marine bivalve lysozyme; MOPS buffer; Tapes japonica; at 37 ℃; pH=7.0; Enzyme kinetics;

DOI:10.1007/s00018-003-3082-z

Reference yield:

α-glutamyl p-nitroanilide (24032-35-7) → L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + 4-nitro-aniline (100-01-6,104810-17-5)

Guidance literature:

With soybean cotyledon N-terminal acidic amino acid-specific aminopeptidase; at 37 ℃; pH=7.2; aq. HEPES buffer; Enzymatic reaction;

DOI:10.1271/bbb.90617

Reference yield:

(43R)-hoshinoamide C → L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) + L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) + L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + N-methyl-D-phenylalanine (56564-52-4) + N-methyl-D-allo-isoleucine (50673-48-8) + L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7)

Guidance literature:

With hydrogenchloride; In water; at 110 ℃; for 24h;

DOI:10.1021/acs.jnatprod.0c01209

upstream raw materials:

α-ketoglutaric acid

L-alanin

L-leucine

L-Cysteic acid

Downstream raw materials:

N-phthaloyl-L-glutamic acid

N-phthalylglutamic acid

N-phthaloylglutamic acid anhydride

N-phthaloyl-L-glutamic anhydride

Refernces

• 1、 Wan, Xinhua,Wang, Zhaoxu,Ye, Xichong,Zhang, Jie. "Noncovalently Functionalized Commodity Polymers as Tailor-Made Additives for Stereoselective Crystallization". supporting information. p. 20243 - 20248. Retrieved 2021/08/09.
• 2、 Li, Tingting,Xu, Bo. "Mechanically Strong Heterogeneous Catalysts via Immobilization of Powderous Catalysts to Porous Plastic Tablets". supporting information. p. 2673 - 2678. Retrieved 2021/08/03.