1-Heptyloxy-2,3-difluorobenzene

Base Information

• Chemical Name: 1-Heptyloxy-2,3-difluorobenzene
• CAS No.: 122265-84-3
• Molecular Formula: C13H18F2O
• Molecular Weight: 228.282
• Hs Code.: 2909309090
• Mol file: 122265-84-3.mol

Synonyms:1-Heptyloxy-2,3-difluorobenzene;

Chemical Property of 1-Heptyloxy-2,3-difluorobenzene

Chemical Property:

• Vapor Pressure: 0.0127mmHg at 25°C
• Refractive Index: 1.461
• Boiling Point: 268.416 °C at 760 mmHg
• Flash Point: 123.429 °C
• PSA: 9.23000
• Density: 1.033 g/cm³
• LogP: 4.31400

Purity/Quality:

99% ^*data from raw suppliers

1,2-Difluoro-3-(heptyloxy)benzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Heptyloxy-2,3-difluorobenzene

There total 5 articles about 1-Heptyloxy-2,3-difluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-Bromoheptane (629-04-9) + 2,3-difluorophenol (6418-38-8) → 2,3-difluoro-4-(heptyloxy)benzene (122265-84-3)

Guidance literature:

With potassium carbonate; In butanone; Heating / reflux;

Reference yield:

1-Bromoheptane (629-04-9) → 2,3-difluoro-4-(heptyloxy)benzene (122265-84-3)

Guidance literature:

With potassium carbonate;

Reference yield:

ortho-difluorobenzene (367-11-3) → 2,3-difluoro-4-(heptyloxy)benzene (122265-84-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 2.5 h / -78 °C

1.2: hexane; tetrahydrofuran / -78 - 20 °C

2.1: 100 percent / 10 percent aq. HCl / 1 h / 20 °C

3.1: 100 percent / 10 percent aq. H₂O₂ / diethyl ether / 2.5 h / Heating

4.1: K₂CO₃ / acetone / 48 h / Heating

With hydrogenchloride; n-butyllithium; dihydrogen peroxide; potassium carbonate; In tetrahydrofuran; diethyl ether; hexane; acetone; 1.1: Metallation / 1.2: Substitution / 2.1: Hydrolysis / 3.1: Oxidation / 4.1: Alkylation;

DOI:10.1039/a902351h

upstream raw materials:

1-Bromoheptane

2,3-difluorophenol

ortho-difluorobenzene

(2,3-difluorophenyl)boronic acid

Downstream raw materials:

2,3-Difluoro-4-n-heptoxyphenylboronic acid

2,3-difluoro-4-(heptyloxy)benzoic acid

Refernces

• 1、 Bedel,Rouillon,Marcerou,Laguerre,Nguyen,Achard. "Influence of fluoro substituents on the mesophase behaviour of banana-shaped molecules". . p. 2214 - 2220. Retrieved 2007/10/03.
• 2、 -. "Dioxane derivatives". . . Retrieved 2008/06/13.