2-(2-bromophenyl)acetamide

Base Information

• Chemical Name: 2-(2-bromophenyl)acetamide
• CAS No.: 65999-53-3
• Molecular Formula: C8H8BrNO
• Molecular Weight: 214.062
• Hs Code.: 2924299090
• Mol file: 65999-53-3.mol

Synonyms:benzeneacetamide, 2-bromo-; 2-(2-Bromophenyl) acetamide

Chemical Property of 2-(2-bromophenyl)acetamide

Chemical Property:

• Vapor Pressure: 1.09E-05mmHg at 25°C
• Refractive Index: 1.591
• Boiling Point: 370.7 °C at 760 mmHg
• Flash Point: 178 °C
• PSA: 43.09000
• Density: 1.537 g/cm³
• LogP: 2.17720

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Bromophenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

Useful:

Technology Process of 2-(2-bromophenyl)acetamide

There total 7 articles about 2-(2-bromophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-(2-bromophenyl)acetonitrile (19472-74-3) → 2-(2-bromophenyl)acetamide (65999-53-3)

Guidance literature:

With potassium hydroxide; In tert-butyl alcohol; for 2h; Inert atmosphere; Reflux;

DOI:10.1002/anie.201104356

Reference yield: 66.0%

Benzeneacetamide (103-81-1) → 2-(2-bromophenyl)acetamide (65999-53-3) + 2-(2,6-dibromophenyl)acetamide

Guidance literature:

With N-Bromosuccinimide; palladium diacetate; trifluoroacetic acid; In 1,2-dichloro-ethane; at 50 ℃; for 24h; Reagent/catalyst; Solvent; Temperature; regioselective reaction; Mechanism; Catalytic behavior; Sealed tube;

DOI:10.1039/c9ob01082c

Reference yield: 43.2%

ortho-bromophenylacetic acid (18698-97-0) → 2-(2-bromophenyl)acetamide (65999-53-3)

Guidance literature:

ortho-bromophenylacetic acid; With thionyl chloride; In toluene; at 60 ℃;

With ammonia; In water; toluene; at 0 - 20 ℃;

upstream raw materials:

2-(2-bromophenyl)acetonitrile

Benzeneacetamide

2-bromophenylacetyl chloride

water

Downstream raw materials:

ortho-bromophenylacetic acid

2-(2-bromophenyl)acetonitrile

(2-bromophenyl)thioacetamide

2-(2-bromophenyl)ethanamine

Refernces

• 1、 Jaiswal, Yogesh,Kumar, Yogesh,Kumar, Amit. "The palladium(ii)-catalyzed regioselective ortho-C-H bromination/iodination of arylacetamides with in situ generated imidic acid as the directing group: Mechanistic exploration". supporting information. p. 6809 - 6820. Retrieved 2019/07/22.
• 2、 You, Tingjie,Wang, Zhenrong,Chen, Jiajia,Xia, Yuanzhi. "Transfer Hydro-dehalogenation of Organic Halides Catalyzed by Ruthenium(II) Complex". . p. 1340 - 1346. Retrieved 2017/02/10.