6-CHLORO-2-HYDROXYPYRAZINE

Base Information

• Chemical Name: 6-CHLORO-2-HYDROXYPYRAZINE
• CAS No.: 4925-61-5
• Molecular Formula: C4H3ClN2O
• Molecular Weight: 130.534
• Hs Code.: 2933990090
• Mol file: 4925-61-5.mol

Synonyms:6-Chloro-2-pyrazinol;6-Chloropyrazin-2-ol;

Chemical Property of 6-CHLORO-2-HYDROXYPYRAZINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.593
• Boiling Point: 419.563 °C at 760 mmHg
• Flash Point: 207.545 °C
• PSA: 46.01000
• Density: 1.513 g/cm³
• LogP: 0.83560
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99.3% ^*data from raw suppliers

6-Chloropyrazin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLORO-2-HYDROXYPYRAZINE

There total 2 articles about 6-CHLORO-2-HYDROXYPYRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2,6-dichloropyrazine (4774-14-5) → 6-chloropyrazin-2(1H)-one (4925-61-5)

Guidance literature:

With water; sodium hydroxide; In 1,4-dioxane; for 4h; Reflux;

DOI:10.1021/acs.orglett.9b00681

Reference yield:

→ 6-chloropyrazine-2-ol (4925-61-5)

Guidance literature:

2-Benzyloxy-6-chlor-pyrazin, alkal. Hydrolyse;

DOI:10.1039/j39710002977

Reference yield: 82.0%

6-chloropyrazine-2-ol (4925-61-5) + 4-(bromomethyl)-3-fluorobenzonitrile (105942-09-4) → 4-(((6-chloropyrazin-2-yl)oxy)methyl)-3-fluorobenzonitrile

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 2h;

upstream raw materials:

2,6-dichloropyrazine

Refernces

• 1、 -. "INHIBITOR OF BTK AND MUTANTS THEREOF". Page/Page column 241. . Retrieved 2020/09/12.