5,7-Dihydroxy-2-isopropylchromone

Base Information

• Chemical Name: 5,7-Dihydroxy-2-isopropylchromone
• CAS No.: 96552-59-9
• Molecular Formula: C₁₂H₁₂O₄
• Molecular Weight: 220.225
• Hs Code.: 2932999099
• Mol file: 96552-59-9.mol

Synonyms:5,7-dihydroxy-2-isopropylchromone;

Chemical Property of 5,7-Dihydroxy-2-isopropylchromone

Chemical Property:

• PSA: 70.67000
• LogP: 2.32760

Purity/Quality:

98%min ^*data from raw suppliers

5,7-Dihydroxy-2-isopropylchromone ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,7-Dihydroxy-2-isopropylchromone

There total 2 articles about 5,7-Dihydroxy-2-isopropylchromone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

2,4,6-trihydroxyacetophenone (480-66-0,67471-34-5) + isobutyric acid sodium salt (996-30-5) → 5,7-dihydroxy-2-isopropyl-4H-chromen-4-one (96552-59-9)

Guidance literature:

With 2-Methylpropionic anhydride; at 180 ℃; for 0.666667h; Microwave irradiation;

Reference yield:

5-hydroxy-4-oxo-2-(propan-2-yl)-4H-chromen-7-yl β-D-glucopyranoside (1131007-60-7) → D-glucose (50-99-7) + 5,7-dihydroxy-2-isopropyl-4H-chromen-4-one (96552-59-9)

Guidance literature:

With water; at 37 ℃; for 60h; Enzymatic reaction;

DOI:10.1016/j.phytochem.2008.11.006

Reference yield:

5,7-dihydroxy-2-isopropyl-4H-chromen-4-one (96552-59-9) → 5-hydroxy-2-isopropyl-4-oxo-4H-chromene-7-carboxylic acid

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

2: pyridine / 16 h / 20 °C

3: zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1-methyl-pyrrolidin-2-one / 2 h / 90 °C / Inert atmosphere

4: sulfuric acid / 1,4-dioxane / 4 h / Reflux

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; zinc; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane;

upstream raw materials:

5-hydroxy-4-oxo-2-(propan-2-yl)-4H-chromen-7-yl β-D-glucopyranoside

2,4,6-trihydroxyacetophenone

isobutyric acid sodium salt

Refernces

• 1、 Tanaka, Naonobu,Kashiwada, Yoshiki,Nakano, Tatsuro,Shibata, Hirofumi,Higuchi, Tomihiko,Sekiya, Michiko,Ikeshiro, Yasumasa,Takaishi, Yoshihisa. "Chromone and chromanone glucosides from Hypericum sikokumontanum and their anti-Helicobacter pylori activities". experimental part. p. 141 - 146. Retrieved 2009/08/07.