8-Hydroxy-2-methyl-5,7-dinitroquinoline

Base Information

• Chemical Name: 8-Hydroxy-2-methyl-5,7-dinitroquinoline
• CAS No.: 38543-75-8
• Molecular Formula: C10H7N3O5
• Molecular Weight: 249.18
• Hs Code.: 2933499090
• Mol file: 38543-75-8.mol

Synonyms:8-Hydroxy-2-methyl-5,7-dinitroquinoline;5,7-Dinitro-2-methyl-8-quinolinol;2-Methyl-5,7-dinitroquinolin-8-ol;5,7-Dinitro-8-hydroxy-2-methylquinoline;

Chemical Property of 8-Hydroxy-2-methyl-5,7-dinitroquinoline

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.731
• Boiling Point: 415.572 °C at 760 mmHg
• Flash Point: 205.131 °C
• PSA: 124.76000
• Density: 1.606 g/cm³
• LogP: 3.11160

Purity/Quality:

98%min ^*data from raw suppliers

2-Methyl-5,7-dinitro-quinolin-8-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Hydroxy-2-methyl-5,7-dinitroquinoline

There total 3 articles about 8-Hydroxy-2-methyl-5,7-dinitroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-methyl-8-quinolinol (826-81-3) → 8-hydroxy-2-methyl-5,7-dinitroquinoline (38543-75-8)

Guidance literature:

With sulfuric acid; nitric acid; at 0 - 20 ℃; for 0.166667h;

DOI:10.1016/j.bmcl.2018.02.042

Reference yield:

→ 2-methyl-5-nitroquinolin-8-ol (38543-66-7) + 8-hydroxy-2-methyl-5,7-dinitroquinoline (38543-75-8)

Guidance literature:

With water; nitric acid;

DOI:10.1039/jr9540000570

Reference yield:

→ 8-hydroxy-2-methyl-5,7-dinitroquinoline (38543-75-8)

Guidance literature:

upstream raw materials:

2-methyl-8-quinolinol

Downstream raw materials:

7-acetamido-2-formylquinoline-5,8-dione

Refernces

• 1、 Cieslik, Wioleta,Spaczynska, Ewelina,Malarz, Katarzyna,Tabak, Dominik,Nevin, Eoghan,O'Mahony, Jim,Coffey, Aidan,Mrozek-Wilczkiewicz, Anna,Jampilek, Josef,Musiol, Robert. "Investigation of the antimycobacterial activity of 8-hydroxyquinolines". . p. 771 - 779. Retrieved 2015/12/01.
• 2、 Majerz-Maniecka, Katarzyna,Musiol, Robert,Skorska-Stania, Agnieszka,Tabak, Dominik,Mazur, Pawel,Oleksyn, Barbara J.,Polanski, Jaroslaw. "X-ray and molecular modelling in fragment-based design of three small quinoline scaffolds for HIV integrase inhibitors". scheme or table. p. 1606 - 1612. Retrieved 2011/04/16.