4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride

Base Information

• Chemical Name: 4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride
• CAS No.: 471843-75-1
• Molecular Formula: C16H16N4O.HCl
• Molecular Weight: 316.79
• Mol file: 471843-75-1.mol

Synonyms:4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride;

Chemical Property of 4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride

Chemical Property:

• PSA: 83.80000
• LogP: 4.41020

Purity/Quality:

98%min ^*data from raw suppliers

Y-39983 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride

There total 5 articles about 4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide (199433-58-4) → Y-39983 (471843-75-1,173897-44-4)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 - 60 ℃; for 3.5h; Cooling with ice;

Reference yield:

(R)-4-(1-benzyloxycarbonylaminoethyl)benzoic acid chloride (173897-73-9) → Y-39983 (471843-75-1,173897-44-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 8 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: hydrogenchloride; 10% palladium hydroxide on charcoal; hydrogen / methanol / 1 h / 40 °C

3.1: sodium hydroxide / water / Cooling with ice

4.1: hydrogenchloride / ethanol / 3.5 h / 20 - 60 °C / Cooling with ice

With hydrogenchloride; 10% palladium hydroxide on charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; ethanol; water; acetonitrile;

Reference yield:

(R)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-benzyloxycarbonylaminoethyl)benzamide (173897-93-3) → Y-39983 (471843-75-1,173897-44-4)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; 10% palladium hydroxide on charcoal; hydrogen / methanol / 1 h / 40 °C

2: sodium hydroxide / water / Cooling with ice

3: hydrogenchloride / ethanol / 3.5 h / 20 - 60 °C / Cooling with ice

With hydrogenchloride; 10% palladium hydroxide on charcoal; hydrogen; sodium hydroxide; In methanol; ethanol; water;

upstream raw materials:

(R)-(+)-4-(1-benzyloxycarbonylaminoethyl)-benzoic acid

(R)-4-(1-benzyloxycarbonylaminoethyl)benzoic acid chloride

(R)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-benzyloxycarbonylaminoethyl)benzamide

(R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide

Refernces