(S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

Base Information Edit

Chemical Name:(S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
CAS No.:935666-88-9
Molecular Formula:C₁₄H₁₄ClFN₈
Molecular Weight:348.77
Hs Code.:29335990
European Community (EC) Number:641-076-0
UNII:KL2Z2TLF01
ChEMBL ID:CHEMBL1231124
DSSTox Substance ID:DTXSID50239469
Metabolomics Workbench ID:153551
NCI Thesaurus Code:C91394
Nikkaji Number:J3.540.767G
Pharos Ligand ID:DYVQLHYJVNTP
Wikidata:Q27074711
Mol file:935666-88-9.mol

Synonyms:5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine;AZD 1480;AZD-1480;AZD1480

Suppliers and Price of (S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
AZD1480
1mg
$ 270.00

TRC
AZD1480
100mg
$ 1415.00

Tocris
AZD1480 ≥98%(HPLC)
10
$ 267.00

Sigma-Aldrich
AZD1480 ≥98% (HPLC)
5mg
$ 113.00

Sigma-Aldrich
AZD1480 ≥98% (HPLC)
25mg
$ 455.00

Matrix Scientific
(S)-5-Chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine 97%
100mg
$ 1432.00

Matrix Scientific
(S)-5-Chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine 97%
50mg
$ 892.00

DC Chemicals
AZD1480 >98%
1 g
$ 2100.00

DC Chemicals
AZD1480 >98%
250 mg
$ 1000.00

DC Chemicals
AZD1480 >98%
100 mg
$ 550.00

Total 38 raw suppliers

Chemical Property of (S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine Edit

Chemical Property:

Boiling Point:575.2±60.0 °C(Predicted)
PKA:13.73±0.10(Predicted)
PSA：107.53000
Density:1.517 g/cm³
LogP:2.50220
Storage Temp.:-20°C
Solubility.:Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly, Heat
XLogP3:2.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:348.1013983
Heavy Atom Count:24
Complexity:397

Purity/Quality:

98%,99%, ^*data from raw suppliers

AZD1480 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=NN1)NC2=NC(=NC=C2Cl)NC(C)C3=NC=C(C=N3)F
Isomeric SMILES:CC1=CC(=NN1)NC2=NC(=NC=C2Cl)N[C@@H](C)C3=NC=C(C=N3)F
Recent ClinicalTrials:Study to Assess the Safety of AZD1480 in Patients With Myeloproliferative Diseases
Recent EU Clinical Trials:A Phase I/II, Open Label Multi-Centre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of the JAK2 inhibitor AZD1480 Administered Orally to Patients with Primary Myelofibrosis (PMF) and Post-Polycythaemia Vera/Essential Thrombocythaemia Myelofibrosis (Post-PV/ET MF)
Uses AZD1480 has been used as an inhibitor of janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) in an in vitro cell model of upper gastrointestinal adenocarcinoma. It has also been used in combination with bortezomib to study tumor-associated macrophage-mediated survival of myeloma cells.

Technology Process of (S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

There total 12 articles about (S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%