3-(2-Methoxy-phenoxy)-benzaldehyde

Base Information

• Chemical Name: 3-(2-Methoxy-phenoxy)-benzaldehyde
• CAS No.: 66855-92-3
• Molecular Formula: C14H12O3
• Molecular Weight: 228.247
• Hs Code.: 2912499000
• Mol file: 66855-92-3.mol

Synonyms:Benzaldehyde, 3-(2-methoxyphenoxy)-;3-(2-Methoxyphenoxy)benzaldehyde;

Chemical Property of 3-(2-Methoxy-phenoxy)-benzaldehyde

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.591
• Boiling Point: 367.728 °C at 760 mmHg
• Flash Point: 167.562 °C
• PSA: 35.53000
• Density: 1.166 g/cm³
• LogP: 3.30000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-(2-Methoxyphenoxy)benzaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-Methoxy-phenoxy)-benzaldehyde

There total 2 articles about 3-(2-Methoxy-phenoxy)-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

3-Formylphenylboronic acid (87199-16-4) + 2-methoxy-phenol (90-05-1) → 3-(2-methoxyphenoxy)benzaldehyde (66855-92-3)

Guidance literature:

With copper diacetate; 4 A molecular sieve; triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 18h;

DOI:10.1021/jm050965z

Reference yield:

→ 3-(2-methoxyphenoxy)benzaldehyde (66855-92-3)

Guidance literature:

Aldehyd (I), Na-Methoxyphenolat;

DOI:10.1021/jf60218a060

Reference yield: 64.0%

3,9-diazaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester hydrochloride (236406-47-6) + 3-(2-methoxyphenoxy)benzaldehyde (66855-92-3) → tert-butyl 9-[3-(2-methoxyphenoxy)benzyl]-3,9-diazaspiro[5.5]undecane-3-carboxylate (912461-49-5)

Guidance literature:

With sodium tris(acetoxy)borohydride; triethylamine; In acetonitrile; Heating / reflux;

upstream raw materials:

3-Formylphenylboronic acid

2-methoxy-phenol

Downstream raw materials:

4-amino-1-[3-(2-methoxyphenoxy)benzyl]piperidine-4-carboxylic acid methyl ester

tert-butyl-4-((1-(3-(2-methoxyphenoxy)benzyl)piperidin-4-yl)carbamoyl)-4-phenylpiperidine-1-carboxylate

tert-butyl 9-[3-(2-methoxyphenoxy)benzyl]-3,9-diazaspiro[5.5]undecane-3-carboxylate

3-[3-(2-methoxyphenoxy)benzyl]-9-(pyrimidin-4-ylcarbonyl)-3,9-diazaspiro[5.5]undecane trifluoroacetate

Refernces

• 1、 -. "NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES". Page/Page column 24-25. . Retrieved 2008/06/13.
• 2、 -. "NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES". Page/Page column 24; 25. . Retrieved 2010/11/24.