NPS 2143 hydrochloride

Base Information

• Chemical Name: NPS 2143 hydrochloride
• CAS No.: 324523-20-8
• Molecular Formula: C24H25ClN2O2.HCl
• Molecular Weight: 445.39
• European Community (EC) Number: 803-657-9
• UNII: U48SZ6EBB3
• Pharos Ligand ID: AMQ826YYZXZ6
• ChEMBL ID: CHEMBL2112075
• Mol file: 324523-20-8.mol

Synonyms:NPS 2143 hydrochloride;324523-20-8;NPS-2143 hydrochloride;NPS-2143 (hydrochloride);NPS-2143 HCL;SB-262470 hydrochloride;U48SZ6EBB3;CHEMBL2112075;2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile;hydrochloride;(R)-2-Chloro-6-(2-hydroxy-3-((2-methyl-1-(naphthalen-2-yl)propan-2-yl)amino)propoxy)benzonitrile hydrochloride;2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile hydrochloride;Benzonitrile, 2-chloro-6-((2R)-3-((1,1-dimethyl-2-(2-naphthalenyl)ethyl)amino)-2-hydroxypropoxy)-, hydrochloride (1:1);Benzonitrile, 2-chloro-6-((2R)-3-((1,1-dimethyl-2-(2-naphthalenyl)ethyl)amino)-2-hydroxypropoxy)-, monohydrochloride;2-CHLORO-6-[(2R)-3-[[1,1-DIMETHYL-2-(2-NAPHTHALENYL)ETHYL]AMINO]-2-HYDROXYPROPOXY]BENZONITRILE HYDROCHLORIDE;NPS-2143hydrochloride;UNII-U48SZ6EBB3;BCP16483;ZMA52320;AKOS024457721;CS-0320;AC-26831;BS-16868;HY-10171;NPS2143 hydrochloride, >=98% (HPLC);C74657;A846766;J-018742;2-Chloro-6-((2R)-3-((1,1-dimethyl-2-(2-naphthalenyl)ethyl)amino)-2-hydroxypropoxy)benzonitrile HCl;2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino-2-hydroxypropoxy]benzonitrile hydrochloride

Chemical Property of NPS 2143 hydrochloride

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: 2-8°C
• Solubility.: DMSO: >10mg/mL
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 444.1371335
• Heavy Atom Count: 30
• Complexity: 560

Purity/Quality:

98%,99%, ^*data from raw suppliers

NPS2143 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 20/21/22-50/53
• Safety Statements: 36/37-60-61

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(CC1=CC2=CC=CC=C2C=C1)NCC(COC3=C(C(=CC=C3)Cl)C#N)O.Cl
• Isomeric SMILES: CC(C)(CC1=CC2=CC=CC=C2C=C1)NC[C@H](COC3=C(C(=CC=C3)Cl)C#N)O.Cl
• Description: Calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is involved in calcium homeostasis. Activation of CaSR on parathyroid cells decreases the secretion of parathyroid hormone (PTH), which in turn reduces blood calcium concentration. NPS 2143 is a potent and selective antagonist of CaSR (IC50 = 43 nM) that stimulates PTH secretion from parathyroid cells in vitro (EC50 = 39 nM). It is effective in vivo, causing a sustained increase in plasma PTH in rats when given intravenously. Daily oral administration of NPS 2143 to osteopenic ovariectomized rats results in a dramatic increase in bone turnover, as well as increased circulating PTH levels.