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Resatorvid

Base Information Edit
  • Chemical Name:Resatorvid
  • CAS No.:243984-11-4
  • Molecular Formula:C15H17ClFNO4S
  • Molecular Weight:361.822
  • Hs Code.:2935909099
  • European Community (EC) Number:897-524-2
  • UNII:H2MZ648C31
  • ChEMBL ID:CHEMBL225157
  • DSSTox Substance ID:DTXSID00947269
  • Metabolomics Workbench ID:149595
  • NCI Thesaurus Code:C87682
  • Nikkaji Number:J2.258.881H
  • Pharos Ligand ID:2TCTF6SYX3C2
  • Wikidata:Q27088534
  • Wikipedia:Resatorvid
  • Mol file:243984-11-4.mol
Resatorvid

Synonyms:CLI 095;CLI-095;CLI095;ethyl (6R)-6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate;ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate;ethyl CFSCC;resatorvid;TAK 242;TAK-242;TAK242

Suppliers and Price of Resatorvid
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Resatorvid
  • 50mg
  • $ 1470.00
  • Tocris
  • TAK242 ≥98%(HPLC)
  • 5
  • $ 192.00
  • Sigma-Aldrich
  • TLR4 Inhibitor, TAK-242 - CAS 243984-11-4 - Calbiochem
  • 5mg
  • $ 203.00
  • Sigma-Aldrich
  • InSolution TLR4 Inhibitor, TAK-242 - CAS 243984-11-4 - Calbiochem
  • 5083360001
  • $ 101.00
  • Sigma-Aldrich
  • InSolution TLR4 Inhibitor, TAK-242 - CAS 243984-11-4 - Calbiochem
  • 2 mg
  • $ 97.12
  • Medical Isotopes, Inc.
  • Resatorvid
  • 50 mg
  • $ 2400.00
  • Medical Isotopes, Inc.
  • Resatorvid
  • 5 mg
  • $ 675.00
  • DC Chemicals
  • TAK-242(Resatorvid) >98%
  • 100 mg
  • $ 900.00
  • DC Chemicals
  • TAK-242(Resatorvid) >98%
  • 50 mg
  • $ 550.00
  • CSNpharm
  • TAK-242
  • 50mg
  • $ 673.00
Total 53 raw suppliers
Chemical Property of Resatorvid Edit
Chemical Property:
  • Vapor Pressure:0mmHg at 25°C 
  • Melting Point:68-69 °C 
  • Refractive Index:1.574 
  • Boiling Point:461.958 °C at 760 mmHg 
  • PKA:7.08±0.40(Predicted) 
  • Flash Point:233.184 °C 
  • PSA:80.85000 
  • Density:1.39 g/cm3 
  • LogP:4.41660 
  • Storage Temp.:Sealed in dry,Room Temperature 
  • Solubility.:insoluble in H2O; ≥100.6 mg/mL in EtOH; ≥18.09 mg/mL in DMSO 
  • XLogP3:3
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:6
  • Rotatable Bond Count:6
  • Exact Mass:361.0550851
  • Heavy Atom Count:23
  • Complexity:560
Purity/Quality:

99% *data from raw suppliers

Resatorvid *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CCOC(=O)C1=CCCCC1S(=O)(=O)NC2=C(C=C(C=C2)F)Cl
  • Isomeric SMILES:CCOC(=O)C1=CCCC[C@H]1S(=O)(=O)NC2=C(C=C(C=C2)F)Cl
  • Recent ClinicalTrials:TAK-242 in Patients With Acute Alcoholic Hepatitis
  • Recent EU Clinical Trials:A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Proof-of-Concept, Phase 2a Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Intravenous TAK-242 in Subjects With Acute Alcoholic Hepatitis Causing Decompensation of Alcohol related Cirrhosis and Acute-on-Chronic Liver Failure
  • Uses Resatorvid is a novel selective Toll-like receptor 4 signal transduction inhibitor. Resatorvid inhibits various kinds of inflammatory mediators such as nitric oxide (NO), tumor necrosis factor (TNF)-α , interleukin (IL)-1, IL-6, IL-10, macrophage inhibitory protein (MIP)-2 and prostaglandin E2 from lipopolysaccharide (LPS)-stimulated macrophages. Resatorvid is a novel selective Toll-like receptor 4 signal transduction inhibitor. Resatorvid inhibits various kinds of inflammatory mediators such as nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, IL-10, macrophage inhibitory protein (MIP)-2 and prostaglandin E2 from lipopolysaccharide (LPS)-stimulated macrophages.
Technology Process of Resatorvid

There total 17 articles about Resatorvid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
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