8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE

Base Information

• Chemical Name: 8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE
• CAS No.: 85333-43-3
• Molecular Formula: C7H6ClN3
• Molecular Weight: 167.60
• Hs Code.: 2933990090
• Mol file: 85333-43-3.mol

Synonyms:8-Chloro-2-methyl-imidazo[1,2-a]pyrazine;8-Chloro-2-methylimidazo[1,2-a]pyrazine;

Chemical Property of 8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE

Chemical Property:

• Refractive Index: 1.681
• PKA: 2.51±0.30(Predicted)
• PSA: 30.19000
• Density: 1.43 g/cm³
• LogP: 1.69110
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

8-Chloro-2-methylimidazo[1,2-a]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE

There total 2 articles about 8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.5%

3-chloropyrazin-2-amine (6863-73-6) + chloroacetone (78-95-5) → 8-chloro-2-methyl-imidazo[1,2-a]pyrazine (85333-43-3)

Guidance literature:

3-chloropyrazin-2-amine; chloroacetone; at 90 ℃; for 16h; sealed tube protected from light;

With sodium carbonate; In water;

Reference yield: 54.0%

3-chloropyrazin-2-amine (6863-73-6) + 1-bromo-2,2-dimethoxypropane (126-38-5) → 8-chloro-2-methyl-imidazo[1,2-a]pyrazine (85333-43-3)

Guidance literature:

1-bromo-2,2-dimethoxypropane; With hydrogenchloride; In water; at 90 ℃; for 0.25h;

With sodium hydrogencarbonate; In water; at 20 ℃;

3-chloropyrazin-2-amine; In water; at 90 ℃; for 2.5h;

Reference yield: 92.0%

8-chloro-2-methyl-imidazo[1,2-a]pyrazine (85333-43-3) → 3-bromo-8-chloro-2-methyl-imidazo[1,2-a]pyrazine (1124321-36-3)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 20 ℃; for 2.5h;

DOI:10.1021/ml400095m

upstream raw materials:

3-chloropyrazin-2-amine

chloroacetone

1-bromo-2,2-dimethoxypropane

Downstream raw materials:

3-amino-2-methyl-8-(2-phenylethyl)imidazo<1,2-a>pyrazine

3-bromo-8-chloro-2-methyl-imidazo[1,2-a]pyrazine

4-[(3-bromo-2-methyl-imidazo[1,2-a]pyrazin-8-ylamino)-methyl]-benzenesulphonamide

3-bromo-2-methyl-N-[(3-methylsulfonylphenyl)methyl]imidazo[1,2-a]pyrazin-8-amine

Refernces

• 1、 -. "INHIBITORS OF PHOSPHODIESTERASE 10 ENZYME". Paragraph 0167; 0168. . Retrieved 2015/07/27.
• 2、 -. "INHIBITORS OF PHOSPHODIESTERASE 10 ENZYME". Page/Page column 31. . Retrieved 2014/02/15.