3-(Benzoxazol-2-yl)benzyl alcohol

Base Information

• Chemical Name: 3-(Benzoxazol-2-yl)benzyl alcohol
• CAS No.: 65540-83-2
• Molecular Formula: C₁₄H₁₁NO₂
• Molecular Weight: 225.247
• Hs Code.: 2934999090
• Mol file: 65540-83-2.mol

Synonyms:Benzenemethanol, 3-(2-benzoxazolyl)-;

Chemical Property of 3-(Benzoxazol-2-yl)benzyl alcohol

Chemical Property:

• Boiling Point: 385.759 °C at 760 mmHg
• Flash Point: 187.1 °C
• PSA: 46.26000
• Density: 1.261 g/cm³
• LogP: 2.98710

Purity/Quality:

99% ^*data from raw suppliers

3-(BENZOXAZOL-2-YL)BENZYL ALCOHOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(Benzoxazol-2-yl)benzyl alcohol

There total 4 articles about 3-(Benzoxazol-2-yl)benzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-(4-methoxycarbonylphenyl)-1,3-benzoxazole (20000-53-7) → 2-(4-hydroxymethylphenyl)benzoxazole (65540-83-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield:

2-chloro-1,3-benzoxazole (615-18-9) + 4-bromobenzenemethanol (873-75-6) → 2-(4-hydroxymethylphenyl)benzoxazole (65540-83-2)

Guidance literature:

With n-butyllithium; acetic acid; In tetrahydrofuran;

Reference yield:

methyl 4-iodobenzoate (619-44-3) → 2-(4-hydroxymethylphenyl)benzoxazole (65540-83-2)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; triphenylphosphine; sodium carbonate / N,N-dimethyl-formamide / 2 h / 160 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

With copper(l) iodide; lithium aluminium tetrahydride; sodium carbonate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

2-chloro-1,3-benzoxazole

4-bromobenzenemethanol

2-(4-methoxycarbonylphenyl)-1,3-benzoxazole

benzoxazole

Refernces

• 1、 -. "AMINO BI- AND TRI-CARBOCYCLIC AKLANE BIS-ARYL SQUALENE SYNTHASE INHIBITORS". . . Retrieved 2008/06/13.