1-Bromo-3-(bromomethyl)-2-methylBenzene

Base Information

• Chemical Name: 1-Bromo-3-(bromomethyl)-2-methylBenzene
• CAS No.: 112299-62-4
• Molecular Formula: C8H8Br2
• Molecular Weight: 263.96
• Hs Code.: 2903999090
• Mol file: 112299-62-4.mol

Synonyms:LogP

Chemical Property of 1-Bromo-3-(bromomethyl)-2-methylBenzene

Chemical Property:

• Vapor Pressure: 0.007mmHg at 25°C
• Melting Point: 31-32℃
• Refractive Index: 1.595
• Boiling Point: 278.749 °C at 760 mmHg
• Flash Point: 138.465 °C
• PSA: 0.00000
• Density: 1.744 g/cm³
• LogP: 3.65240
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-Bromo-3-(bromomethyl)-2-methylbenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Bromo-3-(bromomethyl)-2-methylBenzene

There total 9 articles about 1-Bromo-3-(bromomethyl)-2-methylBenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.8%

3-bromo-2-methylbenzyl alcohol (83647-43-2) → 1-bromo-3-(bromomethyl)-2-methylbenzene (112299-62-4)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In acetonitrile; at 0 ℃; for 1h;

Reference yield: 78.0%

→ 1-bromo-3-(bromomethyl)-2-methylbenzene (112299-62-4) + 1-bromo-2-(bromomethyl)-3-methylbenzene (75366-10-8)

Guidance literature:

Reference yield:

methyl 3-bromo-2-methylbenzoate (99548-54-6) → 1-bromo-3-(bromomethyl)-2-methylbenzene (112299-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2: triphenylphosphine; carbon tetrabromide / acetonitrile / 1 h / 0 °C

With lithium aluminium tetrahydride; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; acetonitrile;

upstream raw materials:

3-bromo-2-methylbenzyl alcohol

3'-bromo-2'-methylbenzonitrile

3-bromo-2-methyl-benzoic acid ethyl ester

3-bromo-2-methylbenzoic acid

Downstream raw materials:

C₁₄H₁₉BrO₂

Refernces

• 1、 -. "Novel biphenyl derivative as well as preparation method and medical application thereof". Paragraph 0046; 0065; 0108-0110. . Retrieved 2021/07/21.
• 2、 Fanourakis, Alexander,Paterson, Kieran J.,Phipps, Robert J.,Williams, Benjamin D.. "Enantioselective Intermolecular C-H Amination Directed by a Chiral Cation". supporting information. p. 10070 - 10076. Retrieved 2021/07/21.