(S)-3-CBZ-AMINO-BUTYLAMINE

Base Information

• Chemical Name: (S)-3-CBZ-AMINO-BUTYLAMINE
• CAS No.: 168828-15-7
• Molecular Formula: C12H18N2O2
• Molecular Weight: 222.28
• Mol file: 168828-15-7.mol

Synonyms:Benzyl [(2S)-4-aminobutan-2-yl]carbamate;

Chemical Property of (S)-3-CBZ-AMINO-BUTYLAMINE

Chemical Property:

• Refractive Index: 1.53
• Boiling Point: 373.764 °C at 760 mmHg
• PKA: 12.23±0.46(Predicted)
• Flash Point: 179.846 °C
• PSA: 64.35000
• Density: 1.086 g/cm³
• LogP: 2.74130
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(S)-3-Cbz-amino-butylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3-CBZ-AMINO-BUTYLAMINE

There total 1 articles about (S)-3-CBZ-AMINO-BUTYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1,1-dimethylethyl phenylmethyl 1,3-butanediylbiscarbamate (878799-19-0) → benzyl (3-amino-1-methylpropyl)carbamate (168828-15-7,885277-95-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.jmedchem.5b01374

Reference yield:

benzyl (3-amino-1-methylpropyl)carbamate (168828-15-7,885277-95-2) → benzyl {3-[(1-adamantylmethyl)amino]-1-methylpropyl}carbamate

Guidance literature:

Multi-step reaction with 2 steps

1: titanium(IV) isopropylate / 20 °C

2: sodium tetrahydroborate / ethanol / 24 h / 20 °C

With titanium(IV) isopropylate; sodium tetrahydroborate; In ethanol;

DOI:10.1021/acs.jmedchem.5b01374

Reference yield:

benzyl (3-amino-1-methylpropyl)carbamate (168828-15-7,885277-95-2) → benzyl (3-{[2-(1-adamantyl)ethyl]amino}-1-methylpropyl)carbamate

Guidance literature:

Multi-step reaction with 2 steps

1: titanium(IV) isopropylate / 20 °C

2: sodium tetrahydroborate / ethanol / 24 h / 20 °C

With titanium(IV) isopropylate; sodium tetrahydroborate; In ethanol;

DOI:10.1021/acs.jmedchem.5b01374

upstream raw materials:

1,1-dimethylethyl phenylmethyl 1,3-butanediylbiscarbamate

Refernces