N-[2-(2-METHYL-1H-INDOL-3-YL)ETHYL]ACETAMIDE

Base Information

• Chemical Name: N-[2-(2-METHYL-1H-INDOL-3-YL)ETHYL]ACETAMIDE
• CAS No.: 39760-01-5
• Molecular Formula: C13H16N2O
• Molecular Weight: 216.283
• Mol file: 39760-01-5.mol

Synonyms:N-[2-(2-Methyl-1H-indol-3-yl)ethyl]acetamide;

Chemical Property of N-[2-(2-METHYL-1H-INDOL-3-YL)ETHYL]ACETAMIDE

Chemical Property:

• Boiling Point: 487.8 °C at 760 mmHg
• Flash Point: 248.8 °C
• PSA: 48.38000
• Density: 1.138 g/cm³
• LogP: 2.99520

Purity/Quality:

99% ^*data from raw suppliers

N-[2-(2-Methyl-1H-indol-3-yl)ethyl]acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(2-METHYL-1H-INDOL-3-YL)ETHYL]ACETAMIDE

There total 8 articles about N-[2-(2-METHYL-1H-INDOL-3-YL)ETHYL]ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-methyl-1H-indole (95-20-5) + N-acetylaminoacetaldehyde dimethyl acetal (62005-48-5) → N-[2-(2-methyl-1H-indol-3-yl)ethyl]acetamide (39760-01-5)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/jo3010028

Reference yield: 77.0%

N-<(4-oxo)-1-pentyl>acetamide (17636-95-2) + phenylhydrazine (100-63-0) → N-[2-(2-methyl-1H-indol-3-yl)ethyl]acetamide (39760-01-5)

Guidance literature:

With hydrogenchloride; acetic acid; Heating;

DOI:10.1016/j.tet.2004.10.006

Reference yield: 45.0%

2-methyl-1H-indole (95-20-5) + N-acetylaminoacetaldehyde dimethyl acetal (62005-48-5) → N-[2-(2-methyl-1H-indol-3-yl)ethyl]acetamide (39760-01-5) + N-[2,2-bis(2-methyl-1H-indol-3-yl)ethyl]acetamide

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/jo3010028

upstream raw materials:

N-<(4-oxo)-1-pentyl>acetamide

phenylhydrazine

N-acetylpyridinium chloride

2-methyl-1H-pyrroline

Downstream raw materials:

2-methyltryptamine

Refernces

• 1、 Yeo, Se Jeong,Liu, Yongxiang,Wang, Xiang. "A one-pot three-component reaction for the preparation of highly functionalized tryptamines". supporting information; experimental part. p. 813 - 818. Retrieved 2012/02/01.
• 2、 Nenajdenko, Valentine G.,Zakurdaev, Eugene P.,Prusov, Eugene V.,Balenkova, Elizabeth S.. "Convenient synthesis of melatonin analogues: 2- and 3-substituted -N-acetylindolylalkylamines". . p. 11719 - 11724. Retrieved 2007/10/03.