1-Methyl-1,7-diazaspiro[4.4]nonane

Base Information

• Chemical Name: 1-Methyl-1,7-diazaspiro[4.4]nonane
• CAS No.: 1158749-77-9
• Molecular Formula: C8H16N2
• Molecular Weight: 140.228
• Hs Code.: 2933990090
• Mol file: 1158749-77-9.mol

Synonyms:1,7-Diazaspiro[4.4]nonane, 1-methyl-;

Chemical Property of 1-Methyl-1,7-diazaspiro[4.4]nonane

Chemical Property:

• Boiling Point: 179 °C at 760 mmHg
• Flash Point: 60.3 °C
• PSA: 15.27000
• Density: 1.01 g/cm³
• LogP: 0.71080
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-METHYL-1,7-DIAZASPIRO[4.4]NONANE 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methyl-1,7-diazaspiro[4.4]nonane

There total 2 articles about 1-Methyl-1,7-diazaspiro[4.4]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl 1-methyl-1,7-diazaspiro[4.4]nonane-7-carboxylate (1192688-70-2) → 1-methyl-1,7-diazaspiro[4,4]nonane (1158749-77-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

t-butyl 1,7-diazaspiro[4.4]nonane-7-carboxylate (646055-63-2) → 1-methyl-1,7-diazaspiro[4,4]nonane (1158749-77-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetonitrile / 0.08 h / 20 °C

1.2: 0.67 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With trifluoroacetic acid; In dichloromethane; acetonitrile;

Reference yield:

4-fluoro-1-nitro-2-(propan-2-yloxy)benzene (28987-46-4) + 1-methyl-1,7-diazaspiro[4,4]nonane (1158749-77-9) → 1-methyl-7-[4-nitro-3-(propan-2-yloxy)phenyl]-1,7-diazaspiro[4.4]nonane (1462951-15-0)

Guidance literature:

With potassium carbonate; hydrazine hydrate; In dimethyl sulfoxide; at 20 ℃;

upstream raw materials:

1,1-dimethylethyl 1-methyl-1,7-diazaspiro[4.4]nonane-7-carboxylate

t-butyl 1,7-diazaspiro[4.4]nonane-7-carboxylate

Downstream raw materials:

2-[3-(3-chlorophenyl)-7-(1-methyl-1,7-diazaspiro[4.4]non-7-yl)-1-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-(1-methylethyl)acetamide

1-methyl-7-[4-nitro-3-(propan-2-yloxy)phenyl]-1,7-diazaspiro[4.4]nonane

Refernces