2-(2-Nitrophenyl)acetaldehyde

Base Information

• Chemical Name: 2-(2-Nitrophenyl)acetaldehyde
• CAS No.: 1969-73-9
• Molecular Formula: C8H7NO3
• Molecular Weight: 165.148
• European Community (EC) Number: 924-638-2
• DSSTox Substance ID: DTXSID90445628
• Nikkaji Number: J1.480.111A
• Mol file: 1969-73-9.mol

Synonyms:2-(2-nitrophenyl)acetaldehyde;1969-73-9;(2-nitrophenyl)acetaldehyde;Benzeneacetaldehyde, 2-nitro-;o-Nitrophenylacetaldehyd;2-nitrophenylacetaldehyde;2-nitrophenylacetoaldehyde;2-Nitrobenzeneacetaldehyde;2-nitro-phenyl-acetaldehyde;SCHEMBL415792;(2-Nitro-phenyl)-acetaldehyde;2-(2-nitrophenyl)-acetaldehyde;DTXSID90445628;PFURPHRKGDQJMN-UHFFFAOYSA-N;BAA96973;AKOS006289525;AB48480;CS-0380519;F74449

Chemical Property of 2-(2-Nitrophenyl)acetaldehyde

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Melting Point: 22.5°C
• Refractive Index: 1.561
• Boiling Point: 285.158 °C at 760 mmHg
• Flash Point: 136.804 °C
• PSA: 62.89000
• Density: 1.257 g/cm³
• LogP: 1.85940
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 165.042593085
• Heavy Atom Count: 12
• Complexity: 176

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(2-Nitrophenyl)acetaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)CC=O)[N+](=O)[O-]

Technology Process of 2-(2-Nitrophenyl)acetaldehyde

There total 29 articles about 2-(2-Nitrophenyl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-hydroxynitrobenzene (88-75-5,78813-12-4) → (2-nitrophenyl)acetaldehyde (1969-73-9)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 84.0%

o-nitrophenylpyruvic acid (5461-32-5) → (2-nitrophenyl)acetaldehyde (1969-73-9)

Guidance literature:

o-nitrophenylpyruvic acid; With morpholine; toluene-4-sulfonic acid; In toluene; Dean-Stark apparatus; Heating / reflux;

With hydrogenchloride; In water; toluene; at 20 ℃; for 1h;

Reference yield: 84.0%

4-[(E)-2-(2-Nitro-phenyl)-vinyl]-morpholine (105423-53-8) → (2-nitrophenyl)acetaldehyde (1969-73-9)

Guidance literature:

With aq. acid; for 1h; Ambient temperature;

DOI:10.1016/S0040-4039(00)86860-4

upstream raw materials:

N,N-dimethyl-2-(2-nitrophenyl)ethenylamine

vinyl acetate

2-nitrobenzenediazonium chloride

tert.-butylnitrite

Downstream raw materials:

(2-nitrophenyl)acetone

3H-indole

3,3'-(o-nitrophenethylidene)di-indole

2,3'-(o-nitrophenethylidene)di-indole

Refernces

• 1、 Bharadwaj, Vinay,Brasch, Nicola E.,Rahman, Mohammad S.,Sampson, Paul,Seed, Alexander J.. "Exploring the Potential of 2-(2-Nitrophenyl)ethyl-Caged N-Hydroxysulfonamides for the Photoactivated Release of Nitroxyl (HNO)". . p. 16448 - 16463. Retrieved 2021/12/06.
• 2、 -. "4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES". Page/Page column 93-94. . Retrieved 2020/11/03.