6-Bromo-2,3-dichloroquinoxaline

Base Information

• Chemical Name: 6-Bromo-2,3-dichloroquinoxaline
• CAS No.: 108229-82-9
• Molecular Formula: C8H3BrCl2N2
• Molecular Weight: 277.935
• Hs Code.: 2933990090
• Mol file: 108229-82-9.mol

Synonyms:6-bromo-2,3-dichloroquinoxaline

Chemical Property of 6-Bromo-2,3-dichloroquinoxaline

Chemical Property:

• Refractive Index: 1.696
• Boiling Point: 326.707 °C at 760 mmHg
• PKA: -6.33±0.48(Predicted)
• Flash Point: 151.387 °C
• PSA: 25.78000
• Density: 1.852 g/cm³
• LogP: 3.69910
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%min ^*data from raw suppliers

6-Bromo-2,3-dichloroquinoxaline 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Bromo-2,3-dichloroquinoxaline

There total 6 articles about 6-Bromo-2,3-dichloroquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-bromo-1,4-dihydroquinoxalin-2,3-dione → 7-bromo-2,3-dichloroquinoxaline (108229-82-9)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide;

DOI:10.1021/acschemneuro.7b00243

Reference yield:

6-bromo-1,4-dihydro-quinoxaline-2,3-dione (1910-90-3) → 7-bromo-2,3-dichloroquinoxaline (108229-82-9)

Guidance literature:

With N,N-dimethyl-formamide; trichlorophosphate; In toluene; at 110 ℃; for 1h;

DOI:10.1002/jhet.3224

Reference yield:

→ 7-bromo-2,3-dichloroquinoxaline (108229-82-9)

Guidance literature:

With phosphorus pentachloride; at 165 - 175 ℃;

DOI:10.1039/jr9490001271

upstream raw materials:

oxalic acid diethyl ester

4-Bromo-benzene-1,2-diamine

6-bromo-1,4-dihydro-quinoxaline-2,3-dione

Refernces

• 1、 Demmer, Charles S.,Rombach, David,Liu, Na,Nielsen, Birgitte,Pickering, Darryl S.,Bunch, Lennart. "Revisiting the Quinoxalinedione Scaffold in the Construction of New Ligands for the Ionotropic Glutamate Receptors". . p. 2477 - 2495. Retrieved 2017.
• 2、 -. "HETEROCYCLIC DERIVATIVES AND USE THEREOF". Paragraph 451; 460-469. . Retrieved 2019/12/25.