C₅₂H₇₀N₄O₈

Base Information

• Chemical Name: C₅₂H₇₀N₄O₈
• CAS No.: 1430817-33-6
• Molecular Formula: C₅₂H₇₀N₄O₈
• Molecular Weight: 879.15
• Mol file: 1430817-33-6.mol

Synonyms:

Chemical Property of C₅₂H₇₀N₄O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₂H₇₀N₄O₈

There total 10 articles about C₅₂H₇₀N₄O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C52H66N4O8 → C52H70N4O8 (1430817-33-6)

Guidance literature:

With sodium cyanoborohydride; In methanol; at 20 ℃; for 5h;

DOI:10.1016/j.cclet.2013.02.014

Reference yield:

cis-1-phenyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid methyl ester → C52H70N4O8 (1430817-33-6)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 16 h / 20 °C

2: diisobutylaluminium hydride / toluene / 1.5 h / -78 °C

3: methanol / 0.5 h / 20 °C

4: sodium cyanoborohydride / methanol / 5 h / 20 °C

With diisobutylaluminium hydride; sodium cyanoborohydride; triethylamine; In methanol; dichloromethane; toluene;

DOI:10.1016/j.cclet.2013.02.014

Reference yield:

levodopa (59-92-7,90638-38-3) → C52H70N4O8 (1430817-33-6)

Guidance literature:

Multi-step reaction with 9 steps

1: thionyl chloride / 72 h / 20 °C

2: sodium acetate; acetic acid / 20 h / 20 °C

3: sodium formate; acetic anhydride / 4 h / 20 °C

4: potassium carbonate / acetone / 10 h / Reflux

5: hydrogenchloride / methanol / 3 h / Reflux

6: triethylamine / dichloromethane / 16 h / 20 °C

7: diisobutylaluminium hydride / toluene / 1.5 h / -78 °C

8: methanol / 0.5 h / 20 °C

9: sodium cyanoborohydride / methanol / 5 h / 20 °C

With hydrogenchloride; thionyl chloride; sodium formate; sodium acetate; acetic anhydride; diisobutylaluminium hydride; sodium cyanoborohydride; potassium carbonate; acetic acid; triethylamine; In methanol; dichloromethane; acetone; toluene; 2: |Pictet-Spengler Synthesis;

DOI:10.1016/j.cclet.2013.02.014

upstream raw materials:

levodopa

C₁₇H₁₇NO₄

L-DOPA methyl ester

C₁₈H₁₇NO₅

Downstream raw materials:

C₄₂H₅₄N₄O₄

Refernces