5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

Base Information

• Chemical Name: 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
• CAS No.: 1134156-31-2
• Molecular Formula: C25H23Cl2N7O4
• Molecular Weight: 556.408
• Hs Code.: 2934999090
• Mol file: 1134156-31-2.mol

Synonyms:5'-O-(4-Cyanobenzyl)-8-[(3,4-dichlorobenzyl)amino]adenosine;

Chemical Property of 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

Chemical Property:

• Boiling Point: 856.3 °C at 760 mmHg
• PKA: 13.04±0.70(Predicted)
• Flash Point: 471.7 °C
• PSA: 164.36000
• Density: 1.63 g/cm³
• LogP: 3.68928
• Storage Temp.: Desiccate at RT
• Solubility.: DMSO: >10mg/mL

Purity/Quality:

99% ^*data from raw suppliers

VER 155008 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: VER 155008 is a novel adenosine-derived inhibitor of heat-shocked protein 70, Hsp70 resulting in an inhibition of cell proliferation of human cancer cell lines. VER-155008 has been used as a heat shock protein 70 (HSP70) inhibitor:to study its effects on human embryonic kidney 293 (HEK293T)?cellsto study its effects on viral mRNA synthesis and protein expression in Vero E6 cellsto determine its effects on the attenuation of seizures in rats

Technology Process of 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

There total 1 articles about 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

4-{(3aR,4R,6R,6aR)-6-[6-amino-8-(3,4-dichlorobenzylamino)purin-9-yl]-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-ylmethoxymethyl}benzonitrile (1134156-55-0) → 5’‐O‐[(4‐cyanophenyl)methyl]‐8‐[[(3,4‐dichlorophenyl)methyl]amino]‐adenosine (1134156-31-2)

Guidance literature:

With trifluoroacetic acid; In water; for 3h;

DOI:10.1021/jm801627a

upstream raw materials:

4-{(3aR,4R,6R,6aR)-6-[6-amino-8-(3,4-dichlorobenzylamino)purin-9-yl]-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-ylmethoxymethyl}benzonitrile

Refernces